| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C9orf152 |
| Uniprot No | Q5JTZ5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-239aa |
| 氨基酸序列 | MEGLPCPCPA LPHFWQLRSH LMAEGSRTQA PGKGPPLSIQ FLRAQYEGLK RQQRTQAHLL VLPKGGNTPA PAESMVNAVW INKERRSSLS LEEADSEVEG RLEEAAQGCL QAPKSPWHTH LEMHCLVQTS PQDTSHQVHH RGKLVGSDQR LPPEGDTHLF ETNQMTQQGT GIPEAAQLPC QVGNTQTKAV ESGLKFSTQC PLSIKNPHRS GKPAYYPFPQ RKTPRISQAA RNLGLYGSA |
| 分子量 | 26.3 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C9orf152蛋白的3篇模拟参考文献及其摘要概括，供参考：
1. **文献名称**：*Structural Characterization and Functional Prediction of C9orf152 Protein Using Bioinformatics Tools*
**作者**：Smith A, et al.
**摘要**：本研究通过生物信息学方法预测了C9orf152的蛋白结构，表明其可能含有保守的α-螺旋结构域，提示其在蛋白质相互作用或膜结合功能中的潜在作用。
2. **文献名称**：*C9orf152 Localizes to the Mitotic Spindle and Regulates Cell Cycle Progression*
**作者**：Johnson B, et al.
**摘要**：通过免疫荧光和基因敲除实验，发现C9orf152在有丝分裂纺锤体上富集，敲低其表达导致细胞周期停滞在G2/M期，提示其在细胞分裂中的关键调控作用。
3. **文献名称**：*Expression Analysis of C9orf152 in Neurodegenerative Disease Models*
**作者**：Lee C, et al.
**摘要**：该研究检测了C9orf152在阿尔茨海默病和帕金森病模型中的表达水平，发现其在小胶质细胞中显著上调，可能与神经炎症通路相关。
4. **文献名称**：*C9orf152 Interacts with Ubiquitin-Proteasome System Components*
**作者**：Zhang Y, et al.
**摘要**：利用酵母双杂交技术，鉴定出C9orf152与多个泛素连接酶存在相互作用，提示其可能参与蛋白质降解或稳态调控过程。
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**注**：以上文献为模拟内容，实际研究中请通过数据库(如PubMed、Google Scholar)以“C9orf152”或相关功能关键词检索最新文献。若需验证具体研究，建议结合基因别名(如HGNC命名)扩展检索。
**Background of the C9orf152 Protein**
The human *C9orf152* gene, located on chromosome 9 (9p13.3), encodes a poorly characterized protein also referred to as Chromosome 9 Open Reading Frame 152. While its exact molecular functions remain unclear, bioinformatics analyses suggest potential roles in cellular stress responses, RNA metabolism, or protein-protein interactions. C9orf152 contains low-complexity regions and intrinsically disordered domains, features often associated with phase separation and participation in membraneless organelles like stress granules.
Interest in C9orf152 has been indirectly spurred by its proximity to the *C9orf72* locus, which is linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, unlike the pathogenic repeat expansions in *C9orf72*, C9orf152 itself has no established direct association with neurodegeneration. Limited studies indicate moderate expression across tissues, with higher levels in the brain, testis, and immune cells. Murine models show embryonic lethality upon knockout, suggesting essential but undefined roles in development.
Current challenges in studying C9orf152 include a lack of specific antibodies, structural data, and functional assays. Its conservation across vertebrates hints at evolutionary importance, yet mechanistic insights are sparse. Further research is needed to elucidate its interactome, regulation, and potential involvement in disease pathways or homeostatic processes. Unraveling C9orf152 biology may contribute to broader understanding of cell stress mechanisms and organelle dynamics.
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