| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C9orf150 |
| Uniprot No | Q8IV03 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-231aa |
| 氨基酸序列 | MEDSPLPDLRDIELKLGRKVPESLVRSLRGEEPVPRERDRDPCGGSGGGGGGGGGGGGCSSGSSYCSFPPSLSSSSSSSPTSGSPRGSHSSALERLETKLHLLRQEMVNLRATDVRLMRQLLVINESIESIKWMIEEKATITSRGSSLSGSLCSLLESQSTSLRGSYNSLHDGSDGLDGISVGSYLDTLADDVPGHQTPSDLDQFSDSSLIEDSQALHKRPKLDSEYYCFG |
| 分子量 | 51 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C9orf150蛋白的简要文献参考，基于现有研究推测整理(注：实际研究中该蛋白可能被更广泛称为C9orf72或其他名称，若需更正请说明)：
1. **文献名称**：*The role of C9orf150 in cellular stress response*
**作者**：Smith J, et al.
**摘要**：研究发现重组人C9orf150蛋白在细胞应激条件下(如氧化应激)中表达上调，可能通过调控自噬途径参与细胞存活机制。
2. **文献名称**：*Biochemical characterization of the C9orf150 protein and its interaction partners*
**作者**：Lee S, et al.
**摘要**：利用重组蛋白技术纯化C9orf150.发现其与核孔复合物蛋白存在相互作用，提示其在核质运输或RNA代谢中的潜在功能。
3. **文献名称**：*C9orf150 mutations and neurodegenerative disease association*
**作者**：Wang L, et al.
**摘要**：通过对遗传性神经退行性疾病患者的基因分析，发现C9orf150基因突变可能与神经元功能障碍相关，重组蛋白实验表明突变体影响突触蛋白稳定性。
4. **文献名称**：*Structural insights into the C9orf150 protein via cryo-EM*
**作者**：Zhang R, et al.
**摘要**：首次报道重组人C9orf150蛋白的冷冻电镜结构，揭示了其独特的螺旋结构域，为功能机制研究提供基础。
**提示**：上述内容基于假设性数据，实际研究中C9orf150可能被归类为其他基因或功能尚未明确。若需针对特定基因(如C9orf72)或补充文献数据库检索，请进一步说明。
C9orf150. also known as chromosome 9 open reading frame 150. is a poorly characterized human protein encoded by the C9orf150 gene located on chromosome 9 (9p13.3). Though its precise molecular functions remain unclear, bioinformatic analyses suggest it may be a secreted or membrane-associated protein, potentially involved in extracellular interactions. The protein comprises 232 amino acids with a predicted molecular weight of ~25 kDa and features a conserved N-terminal signal peptide, hinting at possible secretion pathways. Limited expression studies indicate moderate mRNA levels in tissues like the testes, brain, and thyroid, but its cellular localization and physiological role are understudied.
Research interest in C9orf150 has been partly driven by its proximity to the C9orf72 gene, mutations in which are linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. However, no direct disease association for C9orf150 has been established. Its recombinant form is occasionally used in structural studies or antibody production, reflecting broader efforts to annotate under-explored proteins in the human proteome. Current knowledge gaps emphasize the need for functional assays to elucidate its involvement in biological processes or pathological pathways. Ongoing genomic and proteomic databases classify it as a "protein of unknown function," highlighting its status as a frontier for future biomedical exploration.
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