关键信息
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基因名
gABRg2
- 应用
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别名
gABRg2；Gamma-aminobutyric acid receptor subunit gamma-2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P18507
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表达区间
1-475aa
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氨基酸序列
MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL
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分子量
55.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
The research on the recombinant GABRg2 protein is driven by its critical role in the function of gamma-aminobutyric acid (GABA) receptors, which are the primary inhibitory neurotransmitter receptors in the central nervous system. The GABRg2 subunit is essential for the formation of GABA_A receptors, influencing various physiological processes including anxiety, sedation, and motor control. Abnormalities in GABAergic signaling have been implicated in a variety of neurological disorders such as epilepsy, anxiety disorders, and schizophrenia, making the study of these receptors vital for understanding their mechanisms and developing therapeutics. By generating recombinant GABRg2 proteins, researchers can investigate the structural and functional characteristics of GABA_A receptors in a controlled environment, allowing for more detailed studies of ligand binding, receptor configurations, and pharmacological interactions. This research not only enhances our fundamental understanding of neurotransmission but also opens doors for drug discovery aimed at modulating GABAergic activity, providing potential avenues for the treatment of related psychiatric and neurological conditions. Moreover, advancements in recombinant protein technology facilitate the production of more stable and functional receptor models, fostering the exploration of new therapeutic agents and approaches to restore the balance of inhibitory signaling in the brain.
