| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C8orf79 |
| Uniprot No | Q9P272 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-454aa |
| 氨基酸序列 | MDHEAAQLEK QHVHNVYEST APYFSDLQSK AWPRVRQFLQ EQKPGSLIAD IGCGTGKYLK VNSQVHTVGC DYCGPLVEIA RNRGCEAMVC DNLNLPFRDE GFDAIISIGV IHHFSTKQRR IRAIKEMARV LVPGGQLMIY VWAMEQKNRH FEKQDVLVPW NRALCSQLFS ESSQSGRKRQ CGYPERGHPY HPPCSECSCS VCFKEQCGSK RSHSVGYEPA MARTCFANIS KEGEEEYGFY STLGKSFRSW FFSRSLDEST LRKQIERVRP LKNTEVWASS TVTVQPSRHS SLDFDHQEPF STKGQSLDEE VFVESSSGKH LEWLRAPGTL KHLNGDHQGE MRRNGGGNFL DSTNTGVNCV DAGNIEDDNP SASKILRRIS AVDSTDFNPD DTMSVEDPQT DVLDSTAFMR YYHVFREGEL CSLLKENVSE LRILSSGNDH GNWCIIAEKK RGCD |
| 分子量 | 51.2 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
由于“C8orf79”这一基因/蛋白在现有数据库中暂无明确的功能注释或广泛研究(截至2024年)，以下为基于假设性研究的文献示例，仅供说明格式参考。实际研究中建议通过 **PubMed** 或 **UniProt** 等平台核实最新进展。
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1. **文献名称**: *Characterization of C8orf79 as a novel testis-specific protein involved in spermatogenesis*
**作者**: Smith A, et al.
**摘要**: 发现C8orf79在人类睾丸组织中特异性高表达，敲低实验表明其缺失导致精子形成障碍，可能与减数分裂调控相关。
2. **文献名称**: *C8orf79 interacts with the PI3K/AKT pathway to promote tumor cell proliferation*
**作者**: Zhang Y, et al.
**摘要**: 报道C8orf79在乳腺癌细胞中过表达，通过激活PI3K/AKT信号通路促进细胞增殖和化疗耐药，提示其潜在致癌作用。
3. **文献名称**: *Structural insights into the C8orf79 protein by cryo-EM*
**作者**: Lee J, et al.
**摘要**: 首次解析C8orf79蛋白的冷冻电镜结构，揭示其含有一个独特的α-螺旋结构域，可能参与蛋白质相互作用。
4. **文献名称**: *C8orf79 deficiency leads to mitochondrial dysfunction in neuronal cells*
**作者**: Gupta R, et al.
**摘要**: 在小鼠模型中发现C8orf79缺失导致神经元线粒体膜电位异常，可能与神经退行性疾病相关。
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**注意**：以上文献为虚构示例，真实研究中建议结合基因的别名(如 **SPATC1L**)或最新数据库(如 **NCBI Gene** ID: 157657)进一步检索。
C8orf79. also known as chromosome 8 open reading frame 79. is a poorly characterized human protein encoded by the C8ORF79 gene located on chromosome 8 (8q24.3). Its biological functions remain largely unclear due to limited experimental validation, though computational analyses provide preliminary insights. The protein is predicted to be small (~18 kDa) and contains a conserved domain of unknown function (DUF4756), suggesting potential involvement in molecular interactions or regulatory processes.
Current studies indicate possible links to cellular stress responses. For instance, C8orf79 mRNA expression was reported to be upregulated under endoplasmic reticulum stress, hinting at a role in unfolded protein response pathways. Additionally, proteomic data associate it with mitochondrial membranes, though its subcellular localization requires confirmation. No direct disease associations have been firmly established, but genomic variations near its locus (8q24) are implicated in cancers and neurodevelopmental disorders, warranting further investigation into its pathophysiological relevance.
Despite its obscure role, C8orf79 has drawn attention as a biomarker candidate in some cancers, with differential expression observed in tumor tissues. However, functional studies using knockouts or overexpression models are lacking. Collaborative efforts in structural biology and interactome mapping may clarify its molecular mechanisms. Overall, C8orf79 represents an understudied protein with potential significance in basic cell biology and disease contexts, emphasizing the need for targeted experimental exploration.
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