| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C8orf48 |
| Uniprot No | Q96LL4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-319aa |
| 氨基酸序列 | MAICPELAQTDKSALANLSDETETLKNFTDEVQTSSSFSSSGGRQSSPLTSGSKLEREKQTPSLEQGDTQSELLDYKNYEKKLSKKWINYLKLKDSNFERHQPDTKLPTEITRVSDEELNALQSYCTMKINLIHRRGDSKKKTSSRHKKLHLGLDVEASERDAFSCTVPDELLNRIYFKNMRTTPKQEAAAKQHISYQCPYCNRKRAELALSAFLKQKKTLLESFLLQERIDEHLHTKDFLTRIGEAHQDFPRLSDDPRIIWKRLTEKSHIRYSGFERSETEQKMQRDGNSACHLPFSLPFLKRLTLIKPELVIVNDNV |
| 分子量 | 63.3 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C8orf48蛋白的模拟参考文献示例(注：实际文献可能较少，建议结合最新数据库检索)：
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1. **文献名称**：*Characterization of Recombinant Human C8orf48 Protein and Its Interaction with p53*
**作者**：Wang X, et al.
**摘要**：本研究成功在大肠杆菌中表达并纯化了重组人C8orf48蛋白，发现其在体外可与肿瘤抑制蛋白p53结合，提示其在DNA损伤修复通路中的潜在作用。
2. **文献名称**：*C8orf48 Overexpression Promotes Cell Proliferation in Colorectal Cancer*
**作者**：Lee S, Kim D.
**摘要**：通过重组C8orf48蛋白的功能实验，证实其过表达可激活MAPK信号通路，促进结直肠癌细胞增殖，提示其作为癌症治疗靶点的可能性。
3. **文献名称**：*Structural Analysis of C8orf48 Using Cryo-EM Reveals a Novel Protein Fold*
**作者**：Zhang Y, et al.
**摘要**：首次解析C8orf48蛋白的冷冻电镜结构，揭示其具有独特的α-螺旋束结构域，推测可能参与核内蛋白质相互作用网络。
4. **文献名称**：*C8orf48 Knockdown Induces Autophagy in Hepatocellular Carcinoma Cells*
**作者**：Gupta R, et al.
**摘要**：利用重组C8orf48蛋白制备抗体，实验显示抑制其表达会触发肝癌细胞自噬，表明其在细胞代谢调控中的关键作用。
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建议通过**PubMed**或**UniProt(ID: Q8IUL8)**获取最新研究。如需真实文献，请提供更具体的研究方向以便进一步检索。
**Background of Recombinant Human C8orf48 Protein**
The human C8orf48 protein, encoded by the *C8orf48* gene (Chromosome 8 Open Reading Frame 48), is a poorly characterized protein with limited functional information. Located on chromosome 8p11.21. this gene is conserved across vertebrates, suggesting potential biological significance. C8orf48 is predicted to be a small, soluble protein, potentially involved in intracellular signaling or regulatory processes, though its exact molecular mechanisms remain unclear.
Recombinant versions of C8orf48 are synthesized using expression systems like *E. coli* or mammalian cells, enabling structural and functional studies. Its recombinant form is often tagged for purification and detection. Recent studies hint at its possible association with cellular stress responses and cancer progression. For example, altered *C8orf48* expression has been observed in certain tumors, implying a potential role in oncogenesis or tumor suppression. However, conflicting reports exist, and its clinical relevance is not yet established.
Despite limited data, C8orf48 has garnered interest as a candidate biomarker or therapeutic target. Further research is needed to elucidate its interacting partners, post-translational modifications, and precise contributions to cellular pathways. Current investigations focus on leveraging recombinant C8orf48 to unravel its biological roles, particularly in disease contexts, using techniques like CRISPR screening, proteomics, and functional assays.
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