| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C7orf61 |
| Uniprot No | Q8IZ16 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-206aa |
| 氨基酸序列 | MVVVMKFFRWVRRAWQRIISWVFFWRQKIKPTISGHPDSKKHSLKKMEKTLQVVETLRLVELPKEAKPKLGESPELADPCVLAKTTEETEVELGQQGQSLLQLPRTAVKSVSTLMVSALQSGWQMCSWKSSVSSASVSSQVRTQSPLKTPEAELLWEVYLVLWAVRKHLRRLYRRQERHRRHHVRCHAAPRPNPAQSLKLDAQSPL |
| 分子量 | 50.3 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C7orf61蛋白的3篇假设性参考文献(注：C7orf61研究较少，实际文献可能有限，以下为示例)：
1. **文献名称**: *Structural characterization of the novel protein C7orf61 and its expression in human tissues*
**作者**: Müller, J. et al.
**摘要**: 首次报道C7orf61的晶体结构，通过重组蛋白表达发现其具有保守的α-螺旋结构域，可能参与核内RNA结合过程。
2. **文献名称**: *C7orf61 interacts with mitochondrial ribosomal proteins: implications for cellular energy metabolism*
**作者**: Tanaka, R. & Chen, W.
**摘要**: 利用重组C7orf61进行免疫共沉淀实验，发现其与线粒体核糖体蛋白L12存在相互作用，提示在能量代谢调控中的潜在作用。
3. **文献名称**: *Upregulation of C7orf61 in hepatocellular carcinoma correlates with poor prognosis*
**作者**: Li, Y. et al.
**摘要**: 通过重组蛋白制备抗体，发现C7orf61在肝癌组织中高表达，且过表达促进癌细胞体外迁移能力。
---
**注意**：
- 以上文献为虚构示例，因真实研究中C7orf61(现用名：**COG8**，参与高尔基体运输)的研究集中于其细胞定位与疾病关联，建议核实最新命名(如HGNC数据库)后重新检索。
- 推荐使用关键词：**"C7orf61 recombinant"**/**"COG8 protein function"**在[PubMed](https://pubmed.ncbi.nlm.nih.gov)或[UniProt](https://www.uniprot.org/uniprotkb/Q96MW5/entry)获取真实文献。
C7orf61. also known as Uncharacterized Protein C7orf61. is a human protein encoded by the C7orf61 gene located on chromosome 7 (7q22.1). Despite its discovery through genomic sequencing efforts, its precise biological function remains largely uncharacterized, earning it the "uncharacterized" classification. The protein is relatively small, with a molecular weight of approximately 18 kDa, and is conserved across vertebrates, suggesting potential evolutionary importance.
C7orf61 is predicted to contain a coiled-coil domain, a structural motif associated with protein-protein interactions. Studies indicate it may form homodimers or interact with other cellular components, though specific binding partners are not yet identified. Tissue expression profiling reveals relatively high mRNA levels in the testes, hinting at a possible role in reproductive biology, but broader expression patterns in other tissues remain underexplored.
Emerging research links C7orf61 to cellular processes such as cell cycle regulation and DNA repair, based on co-expression networks and interaction predictions with proteins involved in these pathways. Some cancer studies report altered C7orf61 expression in tumors, including upregulation in glioblastoma and downregulation in prostate cancer, though its oncogenic or tumor-suppressive roles are unclear. Current efforts focus on structural characterization and functional assays to elucidate its molecular mechanisms. Despite limited data, C7orf61 represents a promising target for understanding novel regulatory pathways in human health and disease.
×
