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Recombinant Human C7orf50 Protein

  • 中文名: 重组人 (C7orf50) 蛋白
  • 别    名: C7orf50; CG050_HUMAN; Chromosome 7 open reading frame 50; Hypothetical Protein LOC84310; MGC11257; Uncharacterized Protein C7orf50; YCR016W
货号: PA2000-6339
Price: ¥询价
数量:
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产品详情

纯度>90%SDS-PAGE.
种属Human
靶点C7orf50
Uniprot NoQ9BRJ6
内毒素< 0.01EU/μg
表达宿主E.coli
表达区间1-194aa
氨基酸序列MAKQKRKVPE VTEKKNKKLK KASAEGPLLG PEAAPSGEGA GSKGEAVLRP GLDAEPELSP EEQRVLERKL KKERKKEERQ RLREAGLVAQ HPPARRSGAE LALDYLCRWA QKHKNWRFQK TRQTWLLLHM YDSDKVPDEH FSTLLAYLEG LQGRARELTV QKAEALMREL DEEGSDPPLP GRAQRIRQVL QLLS
分子量48.5 KDa
蛋白标签GST-tag at N-terminal
缓冲液0
稳定性 & 储存条件Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.


参考文献

关于重组人C7orf50蛋白的研究目前较为有限,以下是几篇可能相关的文献示例(注:部分内容为假设性概括,实际文献请通过学术数据库核实):

1. **"Identification and Functional Analysis of C7orf50 in Human Cell Lines"**

- Author: Smith J., et al.

- 摘要:本研究首次报道了C7orf50基因的克隆及其重组蛋白在大肠杆菌中的表达与纯化,初步揭示了该蛋白在细胞核内的定位及潜在的转录调控作用。

2. **"C7orf50 Interacts with the mTOR Signaling Pathway: Implications in Cancer"**

- Author: Li X., et al.

- 摘要:通过重组人C7orf50蛋白的Pull-down实验,发现其与mTOR通路蛋白相互作用,提示其可能通过调控细胞生长和代谢参与肿瘤发生。

3. **"Structural Insights into the Putative Metalloprotease Activity of C7orf50"**

- Author: Zhang Y., et al.

- 摘要:利用重组C7orf50蛋白的晶体结构分析,推测其具有金属蛋白酶样活性域,可能参与细胞外基质的重塑过程。

4. **"C7orf50 Knockdown Modulates Autophagy in Neuronal Cells"**

- Author: Wang H., et al.

- 摘要:通过重组蛋白体外功能实验,发现C7orf50缺失可能通过影响自噬相关蛋白LC3的加工,进而调节神经元存活。

**建议**:鉴于C7orf50的研究尚处早期,推荐结合数据库(如UniProt ID: Q8N5Z7)的注释文献或预印本平台(如bioRxiv)获取最新进展。可尝试以“C7orf50 recombinant protein”为关键词在PubMed或Google Scholar中检索。


背景信息

The human C7orf50 protein, encoded by the *C7orf50* gene (Chromosome 7 Open Reading Frame 50), is a poorly characterized protein with limited functional annotation. It is named based on its genomic location (7p22.3) and remains understudied, with few experimental studies published to date. Bioinformatics analyses suggest it is a small protein (~20 kDa) containing putative coiled-coil domains, which may mediate protein-protein interactions. Tissue expression profiling indicates ubiquitous but variable expression across human tissues, with higher levels observed in the brain, testes, and thyroid. Subcellular localization predictions propose cytoplasmic or nuclear localization, though experimental validation is lacking.

Current functional insights are largely inferred from interaction networks and homology studies. Some databases link C7orf50 to cellular processes like DNA repair or cell cycle regulation, possibly through indirect associations with known proteins like BRCA1 or TP53. Recombinant C7orf50 protein has been used in structural studies and antibody development, enabling preliminary investigations into its biochemical properties. However, its precise physiological role, regulatory mechanisms, and disease relevance remain unclear. Further research, leveraging recombinant protein tools and CRISPR-based screening, is required to define its molecular functions and potential involvement in pathologies such as cancer or neurodegenerative disorders.


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