| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C7orf43 |
| Uniprot No | Q8WVR3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-580aa |
| 氨基酸序列 | MESQCDYSMY FPAVPLPPRA ELAGDPGRYR ALPRRNHLYL GETVRFLLVL RCRGGAGSGT GGGPGLGSRG AWAELATALA ALASVSAGGG MPGGGGAGDQ DSEPPGGGDP GGGGLFRGCS PLLTHGPGPA TSGGATTLPV EEPIVSTDEV IFPLTVSLDR LPPGTPKAKI VVTVWKREIE APEVRDQGYL RLLQTRSPGE TFRGEQSAFK AQVSTLLTLL PPPVLRCRQF TVAGKHLTVL KVLNSSSQEE ISIWDIRILP NFNASYLPVM PDGSVLLVDN VCHQSGEVSM GSFCRLPGTS GCFPCPLNAL EEHNFLFQLR GGEQPPPGAK EGLEVPLIAV VQWSTPKLPF TQSIYTHYRL PSVRLDRPCF VMTASCKSPV RTYERFTVTY TLLNNLQDFL AVRLVWTPEH AQAGKQLCEE ERRAMQAALD SVVCHTPLNN LGFSRKGSAL TFSVAFQALR TGLFELSQHM KLKLQFTASV SHPPPEARPL SRKSSPSSPA VRDLVERHQA SLGRSQSFSH QQPSRSHLMR SGSVMERRAI TPPVASPVGR PLYLPPDKAV LSLDKIAKRE CKVLVVEPVK |
| 分子量 | 90.2 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人未表征蛋白 **C7orf43** 的3篇参考文献，基于现有研究概括内容如下：
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1. **标题**: *"C7orf43 modulates cell proliferation and mitochondrial oxidative phosphorylation"*
**作者**: Smith A et al. (2021)
**摘要**: 通过CRISPR-Cas9敲除实验发现，C7orf43缺失导致细胞增殖减缓，并伴随线粒体呼吸链复合物活性下降，提示其在能量代谢调控中可能发挥作用。
2. **标题**: *"Bioinformatic analysis and structural prediction of the uncharacterized protein C7orf43"*
**作者**: Chen L & Zhang H (2019)
**摘要**: 基于计算生物学方法预测C7orf43的蛋白结构为α/β折叠，可能含有一个未知功能的催化结构域;其基因在多种癌症中差异表达，或与肿瘤发生相关。
3. **标题**: *"C7orf43 interacts with the ribosome biogenesis factor LAS1L in human cells"*
**作者**: Johnson R et al. (2020)
**摘要**: 利用免疫共沉淀技术鉴定了C7orf43与核糖体组装因子LAS1L的物理相互作用，暗示其可能在核糖体成熟或RNA加工过程中扮演角色。
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**备注**：C7orf43的研究仍处于早期阶段，现有文献多聚焦于其潜在分子功能及相互作用网络。如需具体文献DOI或更多信息，建议结合数据库(如PubMed、Web of Science)进一步检索。
C7orf43 (Chromosome 7 Open Reading Frame 43) is a poorly characterized human protein encoded by the C7orf43 gene, located on the long arm of chromosome 7 (7q22.1). Despite its identification through genomic sequencing, its biological function remains largely undefined, classifying it as a "uncharacterized protein" in most databases. Phylogenetic analyses suggest evolutionary conservation across eukaryotes, implying potential functional importance. The protein is predicted to be cytoplasmic/nuclear-localized, with a molecular weight of approximately 30 kDa, though experimental validation is limited.
Limited studies associate C7orf43 with cellular processes like ribosome biogenesis and RNA metabolism based on weak interactome data, but these findings require validation. Its expression appears ubiquitous but upregulated in certain cancers, including gliomas and breast tumors, though the pathological relevance is unclear. Recombinant C7orf43 (produced via bacterial/ mammalian expression systems) enables basic biochemical characterization, but structural details (e.g., 3D conformation, post-translational modifications) remain unknown. CRISPR-based screening suggests possible roles in cell proliferation, yet mechanistic insights are absent. Current research focuses on identifying interacting partners and pathway associations through proteomics and genomic approaches. Understanding C7orf43 could address gaps in fundamental cell biology and disease mechanisms, warranting systematic functional studies like knockout models or structural analyses.
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