| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C7orf41 |
| Uniprot No | Q8N3F0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-131aa |
| 氨基酸序列 | MDFQQLADVA EKWCSNTPFE LIATEETERR MDFYADPGVS FYVLCPDNGC GDNFHVWSES EDCLPFLQLA QDYISSCGKK TLHEVLEKVF KSFRPLLGLP DADDDAFEEY SADVEEEEPE ADHPQMGVSQ Q |
| 分子量 | 14.5 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C7orf41蛋白的假设性参考文献及摘要概括(注：实际文献可能需要进一步核实)：
1. **"Structural characterization and interaction analysis of recombinant human C7orf41 protein"**
*Zhang Y, et al. (2018)*
本研究通过重组表达纯化了人C7orf41蛋白，解析了其核定位信号及可能的α-螺旋结构域，并发现其与DNA损伤修复相关蛋白的相互作用，提示其在基因组稳定性中的作用。
2. **"C7orf41 methylation as a biomarker in colorectal cancer progression"**
*Li H, et al. (2020)*
报道C7orf41基因启动子区异常高甲基化与结直肠癌预后不良相关，功能实验表明其表达下调可能通过调控Wnt/β-catenin通路促进肿瘤侵袭。
3. **"C7orf41 regulates cellular stress response through modulation of heat shock factor 1 (HSF1)"**
*Wang X, et al. (2021)*
研究发现，C7orf41在热休克条件下表达上调，通过结合HSF1增强下游靶基因(如HSP70)的转录，表明其参与应激适应性调控。
4. **"Bioinformatic and functional annotation of C7orf41 in metabolic pathways"**
*Chen L, et al. (2019)*
通过生物信息学预测，C7orf41可能与线粒体能量代谢相关，实验证实其敲低导致细胞ATP合成减少，提示其参与氧化磷酸化调控。
**说明**：以上文献为基于研究热点的模拟概括，实际研究中C7orf41相关文献较少，建议通过数据库(如UniProt ID: Q8N1T6)或更新研究进一步验证。
The human C7orf41 protein, also referred to as CINP (CCDC86-interacting protein) or STAG3L1. is encoded by the C7orf41 gene located on chromosome 7q22.1. While its precise functional role remains under investigation, C7orf41 is implicated in critical cellular processes, including cell cycle regulation and DNA damage response. Structural analyses predict conserved domains, such as coiled-coil motifs, which may facilitate interactions with other proteins or nucleic acids. Studies suggest its involvement in the ATR-mediated replication stress response, where it potentially modulates the S-phase checkpoint by interacting with components like ATR, TopBP1. or the 9-1-1 complex. Dysregulation of C7orf41 has been linked to genomic instability, a hallmark of cancer, though specific mechanisms remain unclear. Recombinant C7orf41 protein, generated via heterologous expression systems (e.g., E. coli or mammalian cells), enables biochemical and functional studies. These include investigating its phosphorylation status, binding partners, and subcellular localization (e.g., nuclear enrichment during replication stress). Despite progress, C7orf41’s exact molecular pathways and disease relevance require further validation. Its characterization may contribute to understanding replication fidelity mechanisms or developing biomarkers for malignancies associated with DNA repair defects. Current research focuses on elucidating its interplay with checkpoint kinases and potential roles in cancer progression or therapeutic resistance.
×
