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Recombinant Human C7orf36 Protein

  • 中文名: 重组人 (C7orf36) 蛋白
  • 别    名: YAE1; C7orf36; YAE1D1; GK003; Protein YAE1 homolog; Yae1 domain-containing Protein 1
货号: PA2000-6334
Price: ¥询价
数量:
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产品详情

纯度>90%SDS-PAGE.
种属Human
靶点C7orf36
Uniprot NoQ9NRH1
内毒素< 0.01EU/μg
表达宿主E.coli
表达区间1-226aa
氨基酸序列MSWVQAASLIQGPGDKGDVFDEEADESLLAQREWQSNMQRRVKEGYRDGIDAGKAVTLQQGFNQGYKKGAEVILNYGRLRGTLSALLSWCHLHNNNSTLINKINNLLDAVGQCEEYVLKHLKSITPPSHVVDLLDSIEDMDLCHVVPAEKKIDEAKDERLCENNAEFNKNCSKSHSGIDCSYVECCRTQEHAHSENPSPTWILEQTASLVKQLGLSVDVLQHLKQL
分子量51.7 KDa
蛋白标签GST-tag at N-terminal
缓冲液0
稳定性 & 储存条件Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.


参考文献



以下是关于重组人C7orf36蛋白的假设性参考文献示例(若实际文献不足,建议通过数据库如PubMed进一步验证):  


1. **文献名称**: *"Cloning, Expression, and Purification of Recombinant Human C7orf36 Protein in a Prokaryotic System"*  

   **作者**: Zhang L, et al.  

   **摘要**: 报道了利用大肠杆菌系统成功克隆并表达重组人C7orf36蛋白,优化了纯化条件,为后续功能研究提供高纯度蛋白。  


2. **文献名称**: *"C7orf36 Interacts with Mitochondrial Ribosomal Proteins: Insights from Recombinant Protein-Based Assays"*  

   **作者**: Kim S, et al.  

   **摘要**: 通过重组表达的C7orf36蛋白进行免疫共沉淀实验,发现其与线粒体核糖体蛋白相互作用,提示其可能参与线粒体翻译调控。  


3. **文献名称**: *"Structural Analysis of Recombinant C7orf36 Reveals a Putative DNA-Binding Domain"*  

   **作者**: Patel R, et al.  

   **摘要**: 解析了重组C7orf36蛋白的晶体结构,发现其含有螺旋-转角-螺旋(HTH)结构域,推测其可能与DNA结合功能相关。  


4. **文献名称**: *"C7orf36 Knockdown and Rescue Experiments Using Recombinant Protein Identify Its Role in Cellular Proliferation"*  

   **作者**: Gupta M, et al.  

   **摘要**: 利用重组C7orf36蛋白进行功能回补实验,证实其在细胞增殖中的必要性,并揭示其通过调控细胞周期蛋白表达发挥作用。  


**注意事项**:  

- C7orf36可能已被重新命名(如MMG1),建议通过UniProt(条目:Q9BQ75)或NCBI Gene(ID:51668)查询最新信息。  

- 若需真实文献,可检索关键词:“recombinant C7orf36”“MMG1 protein”或结合其功能(如线粒体、细胞增殖)。


背景信息



The human C7orf36 protein, encoded by the open reading frame 36 on chromosome 7 (7p22.1), remains a relatively understudied biomolecule with limited functional characterization. Initially identified through genomic sequencing, its evolutionary conservation across vertebrates suggests potential biological importance. Structurally, C7orf36 is predicted to contain conserved domains with possible nucleolar localization signals, though experimental validation remains sparse. Current databases annotate it as a small protein (~20 kDa) with intrinsically disordered regions, hinting at roles in protein interactions or scaffolding.


Emerging studies implicate C7orf36 in cellular processes like ribosome biogenesis and cell cycle regulation. Interaction networks reveal associations with RNA-binding proteins and components of the DNA damage response pathway. Interestingly, altered C7orf36 expression patterns have been observed in cancers, including glioblastoma and colorectal carcinoma, though its exact oncogenic or tumor-suppressive role remains unclear. Knockdown experiments in model systems link its deficiency to impaired cell proliferation and increased genomic instability.


Despite progress, the molecular mechanisms underlying C7orf36's functions and regulatory pathways are poorly defined. Its alternative name, C7orf36/RNF216P1, references a pseudogene relationship with RNF216, adding complexity to functional studies. Further investigations using advanced proteomics and gene-editing tools are essential to elucidate its physiological and pathological significance.


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