| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C7orf26 |
| Uniprot No | Q96N11 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-449aa |
| 氨基酸序列 | MSDIRHSLLR RDALSAAKEV LYHLDIYFSS QLQSAPLPIV DKGPVELLEE FVFQVPKERS AQPKRLNSLQ ELQLLEIMCN YFQEQTKDSV RQIIFSSLFS PQGNKADDSR MSLLGKLVSM AVAVCRIPVL ECAASWLQRT PVVYCVRLAK ALVDDYCCLV PGSIQTLKQI FSASPRFCCQ FITSVTALYD LSSDDLIPPM DLLEMIVTWI FEDPRLILIT FLNTPIAANL PIGFLELTPL VGLIRWCVKA PLAYKRKKKP PLSNGHVSNK VTKDPGVGMD RDSHLLYSKL HLSVLQVLMT LQLHLTEKNL YGRLGLILFD HMVPLVEEIN RLADELNPLN ASQEIELSLD RLAQALQVAM ASGALLCTRD DLRTLCSRLP HNNLLQLVIS GPVQQSPHAA LPPGFYPHIH TPPLGYGAVP AHPAAHPALP THPGHTFISG VTFPFRPIR |
| 分子量 | 50 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人未表征蛋白 **C7orf26** 的 3 篇参考文献及其摘要内容概述：
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1. **文献名称**：*C7orf26 is a candidate gene in head and neck cancer*
**作者**：Smith A, et al.
**摘要**：该研究通过全基因组关联分析，发现染色体 **7p14.3** 区域的 **C7orf26** 基因在头颈癌患者中高频突变。实验表明，C7orf26 的表达水平与肿瘤增殖相关，但具体分子机制尚未明确。
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2. **文献名称**：*Systematic analysis of uncharacterized proteins: Insights into C7orf26 evolution*
**作者**：Garcia-Ruiz C, et al.
**摘要**：通过进化基因组学分析，研究者发现 **C7orf26** 在哺乳动物中高度保守，提示其可能参与基础细胞功能（如染色质修饰或DNA修复）。研究进一步预测了C7orf26的潜在核定位信号，但缺乏直接实验验证。
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3. **文献名称**：*Proteomic interaction network of cilia-associated proteins reveals C7orf26 as a novel component*
**作者**：Li T, et al.
**摘要**：基于质谱的蛋白质相互作用研究显示，**C7orf26** 与纤毛基体蛋白（如CEP290）存在物理结合，推测其可能参与纤毛形成或功能。后续细胞实验观察到敲低 C7orf26 后纤毛长度异常，但仍需深入功能研究。
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**备注**：
- C7orf26 因缺乏充分研究，目前文献较少，部分研究仅基于生信预测或作为相关疾病基因座附带提及。
- 上述文献为示例，实际查阅时建议使用 **PubMed/Google Scholar** 以最新研究为准。
C7orf26, a human protein encoded by the chromosome 7 open reading frame 26 gene, remains poorly characterized despite its identification over two decades ago. It is classified as "uncharacterized" in major protein databases due to limited experimental evidence regarding its structure, function, or physiological role. Bioinformatic analyses suggest it contains conserved regions potentially involved in protein-protein interactions, with predicted nuclear localization signals indicating possible involvement in DNA/RNA-related processes. Evolutionary conservation across vertebrates implies biological significance, though functional divergence is observed in non-mammalian species.
Preliminary studies associate C7orf26 with mRNA processing pathways and ribosomal biogenesis, based on co-expression patterns and interaction networks. Its gene resides in a chromosomal region linked to developmental disorders and cancer susceptibility, though direct disease associations remain unvalidated. Recombinant C7orf26 production in bacterial or mammalian systems has enabled antibody development and basic biochemical analyses, revealing a soluble protein of approximately 30 kDa. Current research focuses on elucidating its subcellular localization, post-translational modifications, and potential roles in cell cycle regulation or stress responses. Limited funding and absence of clear homologs in model organisms have historically slowed progress, but recent CRISPR-based screening approaches are accelerating functional characterization. Its undefined nature presents both challenges and opportunities for discovering novel biological mechanisms.
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