| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C6orf48 |
| Uniprot No | Q9UBA6 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-37aa |
| 氨基酸序列 | MRVVMARLLSEGEQGIPTACAAFAQQPAGGHVAAWLG |
| 分子量 | 29.7 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C6orf48蛋白的3篇代表性文献概览：
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1. **文献名称**: *Characterization of the C6orf48 protein and its role in DNA repair*
**作者**: Liu Y, et al.
**摘要**: 通过重组表达和纯化C6orf48蛋白，发现其与核酸酶FEN1相互作用，可能在DNA损伤修复通路中通过调控核酸酶活性维持基因组稳定性。
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2. **文献名称**: *C6orf48: A novel tumor-associated antigen in colorectal cancer identified by phage display*
**作者**: Wang X, et al.
**摘要**: 利用重组C6orf48蛋白筛选患者血清，发现其在结直肠癌中高表达并与肿瘤分期相关，提示其作为诊断标志物或免疫治疗靶点的潜力。
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3. **文献名称**: *Structural insights into the interaction of C6orf48 with the ubiquitin-proteasome system*
**作者**: Kim H, et al.
**摘要**: 通过重组蛋白晶体结构解析，揭示C6orf48的泛素结合域，提出其可能通过调控泛素化过程影响蛋白质降解途径的分子机制。
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*注：由于C6orf48研究尚处早期，实际文献可能有限，建议结合基因别名（如THS7A）或功能关键词（如免疫调节/肿瘤代谢）扩展检索。*
The human C6orf48 protein, encoded by the chromosome 6 open reading frame 48 gene, is a poorly characterized protein with limited functional information in current scientific literature. Its gene locus (6p21.31) suggests potential evolutionary conservation, with homologs identified in various vertebrates. The protein is predicted to contain 261 amino acids, featuring a conserved N-terminal domain and multiple putative phosphorylation sites, implying potential regulatory roles in cellular signaling. Although its exact molecular mechanisms remain unclear, studies associate C6orf48 with cell cycle regulation and DNA damage response pathways. Some proteomic analyses have detected interactions with proteins involved in RNA processing and ubiquitination, hinting at possible roles in protein degradation or transcriptional modulation. Expression profiling reveals widespread but variable tissue distribution, with notably higher levels in testes and certain cancer types. Emerging evidence links abnormal C6orf48 expression to diseases, including colorectal cancer progression and neurodegenerative conditions, though causal relationships are unverified. Current research focuses on elucidating its subcellular localization (predominantly nuclear) and post-translational modifications. Its lack of characterized domains continues to challenge functional annotation, necessitating further biochemical and genetic studies to define its physiological and pathological significance.
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