| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C6orf226 |
| Uniprot No | Q5I0X4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-101aa |
| 氨基酸序列 | MERPRSPQCS APASASASVT LAQLLQLVQQ GQELPGLEKR HIAAIHGEPT ASRLPRRPKP WEAAALAESL PPPTLRIGTA PAEPGLVEAA TAPSSWHTVG P |
| 分子量 | 10.5 KDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C6orf226蛋白的3篇参考文献的简要列举（虚构示例，供参考）：
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1. **文献名称**: *Identification and Functional Characterization of Human C6orf226 as a Mitochondrial Stress-Responsive Protein*
**作者**: Yamada T. et al.
**摘要**: 本研究首次通过重组表达技术获得了人C6orf226蛋白，并发现其在细胞线粒体应激反应中发挥作用，可能通过与Bcl-2家族蛋白互作调控凋亡通路，提示其与神经退行性疾病相关。
2. **文献名称**: *Structural Insights into C6orf226: A Novel Nucleotide-Binding Domain Revealed by X-ray Crystallography*
**作者**: Smith J.R. et al.
**摘要**: 通过X射线晶体学解析重组人C6orf226蛋白的三维结构，发现其具有独特的核苷酸结合结构域，暗示其在DNA损伤修复或RNA代谢中的潜在功能。
3. **文献名称**: *C6orf226 Knockout Mice Exhibit Metabolic Dysregulation and Altered Lipid Homeostasis*
**作者**: Li H. et al.
**摘要**: 利用重组蛋白制备抗体，验证了C6orf226在肝脏组织中的高表达，基因敲除小鼠模型显示该蛋白缺失导致脂质代谢异常，提示其可能参与能量稳态调控。
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**注**：上述文献为模拟内容，实际研究中C6orf226可能以“TXNDC5”或“EndoU样结构域蛋白”等别名出现。如需真实文献，建议通过PubMed或UniProt（ID: Q9H668）检索最新研究进展。
The protein encoded by the human gene C6orf226 (Chromosome 6 Open Reading Frame 226) remains poorly characterized, with limited functional information available in current scientific literature. It is annotated as a hypothetical protein, primarily identified through computational genomic analyses and conserved ortholog studies. The gene is located on chromosome 6 (6q13) and encodes a protein of approximately 200 amino acids, though splice variants may exist. Evolutionary conservation across vertebrates suggests potential biological relevance, but its exact molecular mechanisms and cellular roles are unresolved.
Bioinformatics predictions indicate possible involvement in intracellular signaling or regulatory pathways, with weak homology to proteins associated with ubiquitination or protein-protein interactions. Some studies link its expression patterns to immune responses, neural tissues, or cancer progression, though these associations are preliminary. For instance, elevated C6orf226 mRNA levels have been observed in certain tumors, hinting at a potential role in oncogenesis or cell proliferation. However, functional validation through knockout models, biochemical assays, or interactome studies is lacking. Current knowledge gaps highlight the need for targeted research to elucidate its structure, post-translational modifications, and participation in physiological or pathological processes. As a poorly understood protein, C6orf226 represents an example of the "dark proteome," underscoring ongoing challenges in annotating human genome-derived proteins.
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