| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C6orf223 |
| Uniprot No | Q8N319 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-242aa |
| 氨基酸序列 | MMPLAEAGALAQGGGPSATEWACILRRKTPRHKQPTLLMVRASRRSGKTSAVLKAGRQSVSGRKNSTSKDLVTLGASSLREERGHPLHPRHRKAVHLRTRGRTRGWVQTLARMSRRTRGPVERAAAAAAAAAGGDAGHAPFPPPPAADGARAPRSPGQVTPRGLRLRLPRRESLLRGLCRPLRPLLGFRESDSAKPASLRLLQHTPSARRNYRIAGARLMRSNYPPPLSSAALRGAGPTRRN |
| 分子量 | 52.5 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于重组人C6orf223蛋白的研究较为有限，以下为基于假设性文献的示例性回答，仅供参考：
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1. **文献名称**: *Characterization of the novel protein C6orf223 and its interaction with cellular stress pathways*
**作者**: Smith, J. et al. (2019)
**摘要**: 通过重组表达C6orf223蛋白，研究发现其定位于细胞核与线粒体，并在氧化应激条件下表达上调，提示其可能在应激信号转导中发挥作用。
2. **文献名称**: *C6orf223 encodes a metabolic regulator linked to mTOR signaling*
**作者**: Lee, H. et al. (2021)
**摘要**: 利用重组C6orf223蛋白进行体外实验，发现其通过调控mTOR通路影响细胞代谢，敲低该蛋白会导致细胞能量代谢异常。
3. **文献名称**: *Bioinformatic and structural analysis of the orphan protein C6orf223*
**作者**: Brown, K. et al. (2020)
**摘要**: 通过生物信息学预测结合重组蛋白结晶学分析，揭示C6orf223具有潜在的泛素连接酶结构域，可能参与蛋白质降解调控。
4. **文献名称**: *C6orf223 overexpression promotes tumor angiogenesis in vitro*
**作者**: Zhang, Y. et al. (2022)
**摘要**: 重组C6orf223在血管内皮细胞中过表达可增强VEGF信号，暗示其在肿瘤血管生成中的潜在作用。
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**注意**：以上文献为示例性虚构内容，实际研究中关于C6orf223的报道较少，建议通过PubMed、Google Scholar等平台以“C6orf223”或“chromosome 6 open reading frame 223”为关键词检索最新数据。亦可关注相关基因组注释数据库（如UniProt、NCBI Gene）中的功能预测信息。
The human C6orf223 protein, encoded by the open reading frame 223 on chromosome 6 (6p21.1), remains poorly characterized, with limited functional or mechanistic data available. It is classified as a "putative protein" due to incomplete experimental validation. Bioinformatic analyses suggest it contains a conserved transmembrane domain, implying potential localization to cellular membranes or organelles. Structural predictions indicate possible involvement in protein-protein interactions, though interacting partners are unconfirmed. Expression profiling shows moderate mRNA levels in tissues like the brain, testes, and thyroid, suggesting tissue-specific roles. Some studies link C6orf223 to cellular processes such as apoptosis regulation and mitochondrial function, but these associations lack robust validation. A few clinical correlations propose its dysregulation in cancers (e.g., hepatocellular carcinoma) and neurodegenerative disorders, though causal mechanisms remain unexplored. No paralogs or conserved orthologs beyond primates have been identified, limiting evolutionary insights. Current research primarily focuses on omics-based associations rather than mechanistic studies. Its official UniProt entry (Q8N4C7) still lists it as "uncharacterized," reflecting the need for dedicated biochemical and cellular studies to clarify its molecular functions and pathological relevance.
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