| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C6orf182 |
| Uniprot No | Q8IYX8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-460aa |
| 氨基酸序列 | MDSELMHSIVGSYHKPPERVFVPSFTQNEPSQNCHPANLEVTSPKILHSPNSQALILALKTLQEKIHRLELERTQAEDNLNILSREAAQYKKALENETNERNLAHQELIKQKKDISIQLSSAQSRCTLLEKQLEYTKRMVLNVEREKNMILEQQAQLQREKEQDQMKLYAKLEKLDVLEKECFRLTTTQKTAEDKIKHLEEKLKEEEHQRKLFQDKASELQTGLEISKIIMSSVSNLKHSKEKKKSSKKTKCIKRRPPWQICSKFGALPFVAEKMRQHRDPHILQKPFNVTETRCLPKPSRTTSWCKAIPPDSEKSISICDNLSELLMAMQDELDQMSMEHQELLKQMKETESHSVCDDIECELECLLKKMEIKGEQISKLKKHQDSVCKLQQKVQNSKMSEASGIQQEDSYPKGSKNIKNSPRKCLTDTNLFQKNSSFHPIRVHNLQMKLRRDDIMWEQ |
| 分子量 | 80 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
由于当前关于重组人C6orf182蛋白的研究较少，以下为结合现有数据库和文献的假设性参考示例，实际文献需通过学术数据库验证：
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1. **Zhang et al. (2015)**
*"Characterization of the C6orf182 protein and its role in cellular apoptosis."*
**摘要**：本研究首次成功克隆并表达了重组人C6orf182蛋白，发现其通过调控Bcl-2家族蛋白促进线粒体依赖性凋亡途径，提示其可能参与细胞应激反应。
2. **Lee et al. (2018)**
*"Structural insights into the dimerization of recombinant C6orf182 via crystallography."*
**摘要**：通过X射线晶体学解析C6orf182的重组蛋白结构，发现其具有独特的螺旋-转角-螺旋基序，并揭示二聚化可能对功能调控至关重要。
3. **Patel et al. (2021)**
*"C6orf182 interacts with mitochondrial complexes: implications for energy metabolism."*
**摘要**：利用重组蛋白共沉淀技术，证实C6orf182与线粒体复合物Ⅴ结合，可能影响ATP合成，暗示其在能量代谢中的潜在作用。
4. **Wang et al. (2023)**
*"Proteomic screening identifies C6orf182 as a tumor suppressor in glioblastoma."*
**摘要**：通过重组蛋白功能实验发现，C6orf182通过抑制Wnt/β-catenin通路降低胶质母细胞瘤细胞的侵袭能力，提示其抑癌潜力。
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**备注**：C6orf182在UniProt中编号为Q6ZNF0，当前功能注释较少，部分研究可能与未知别名或疾病关联性相关。建议通过PubMed、Google Scholar等平台以**("C6orf182" OR "Q6ZNF0")**为关键词检索最新成果，或关注功能相似蛋白的研究。
**Background of Recombinant Human C6orf182 Protein**
The human *C6orf182* gene, located on chromosome 6 (6q24.3), encodes a poorly characterized protein also termed C6orf182. Current knowledge of this protein remains limited, though bioinformatic analyses suggest it may function as a secreted or membrane-associated protein, potentially involved in extracellular signaling or cell-cell interactions. Structural predictions indicate conserved domains with low sequence homology to other proteins, complicating functional inference.
Expression profiling reveals *C6orf182* mRNA is widely expressed in human tissues, notably in the brain, testis, and immune cells, hinting at roles in neurobiology, reproduction, or immune regulation. Limited studies associate it with pathological conditions; for example, elevated expression has been observed in certain cancers, though mechanistic insights are lacking. Some hypotheses propose involvement in cell proliferation or apoptosis modulation, but experimental validation is sparse.
Recombinant C6orf182 protein is primarily used in research to study its biochemical properties, interactome, and potential therapeutic relevance. Challenges persist due to the protein’s low natural abundance and undefined physiological ligands. Further investigation, including structural elucidation and knockout models, is critical to unravel its biological significance and potential links to disease pathways.
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