| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C6orf139 |
| Uniprot No | Q7L2Z9 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-268aa |
| 氨基酸序列 | MSGKANASKKNAQQLKRNPKRKKDNEEVVLSENKVRNTVKKNKNHLKDLSSEGQTKHTNLKHGKTAASKRKTWQPLSKSTRDHLQTMMESVIMTILSNSIKEKEEIQYHLNFLKKRLLQQCETLKVPPKKMEDLTNVSSLLNMERARDKANEEGLALLQEEIDKMVETTELMTGNIQSLKNKIQILASEVEEEEERVKQMHQINSSGVLSLPELSQKTLKAPTLQKEILALIPNQNALLKDLDILHNSSQMKSMSTFIEEAYKKLDAS |
| 分子量 | 55.22 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人（C6orf139）蛋白的3篇示例性文献参考（内容基于假设性研究，实际文献需检索数据库补充）：
1. **文献名称**：*C6orf139 regulates mitochondrial dynamics and apoptosis in cancer cells*
**作者**：Smith A, et al.
**摘要**：研究揭示了C6orf139蛋白通过调控线粒体分裂蛋白Drp1的活性影响癌细胞凋亡，重组蛋白实验表明其过表达可抑制肿瘤生长。
2. **文献名称**：*Structural characterization of recombinant human C6orf139 and its interaction with DNA repair machinery*
**作者**：Wang L, et al.
**摘要**：利用重组C6orf139蛋白解析其晶体结构，发现其通过C端结构域与DNA损伤修复复合物（如BRCA1）结合，提示在基因组稳定性中的作用。
3. **文献名称**：*C6orf139 modulates TGF-β signaling via direct binding to Smad4*
**作者**：Chen H, et al.
**摘要**：通过重组蛋白pull-down实验，证明C6orf139与Smad4相互作用，负调控TGF-β通路活性，影响细胞分化及纤维化进程。
（注：上述内容为示例，实际文献需通过PubMed、Google Scholar等平台以“C6orf139”或“chromosome 6 open reading frame 139”为关键词检索。）
**Background of Recombinant Human C6orf139 Protein**
The C6orf139 protein, encoded by the *C6orf139* gene (chromosome 6 open reading frame 139), is a poorly characterized protein with limited functional information. It is also referred to as MPDL (mitotic phosphoprotein enriched in dense lattices) due to its association with mitotic structures in early studies. The gene resides on chromosome 6p21.31 and encodes a protein with a predicted molecular weight of ~25 kDa. Structurally, C6orf139 is suggested to contain coiled-coil domains, indicative of potential roles in protein-protein interactions or structural organization.
While its exact biological function remains unclear, preliminary studies link C6orf139 to cellular processes such as mitosis, cell cycle regulation, and stress response. Expression profiling indicates its ubiquitous presence in tissues, with elevated levels observed in proliferative cells. Intriguingly, altered C6orf139 expression has been implicated in certain cancers, including colorectal and hepatocellular carcinoma, though its role as an oncogene or tumor suppressor remains debated.
Recombinant C6orf139 protein is often utilized in vitro to study its biochemical properties or interactions. However, a lack of specific antibodies or functional assays hampers detailed mechanistic insights. Recent omics studies suggest possible associations with drug resistance pathways, emphasizing the need for further research to clarify its physiological and pathological significance. Current efforts focus on elucidating its interactome and post-translational modifications to unravel its contribution to cellular homeostasis or disease.
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