| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C6orf136 |
| Uniprot No | Q5SQH8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-172aa |
| 氨基酸序列 | MEEHLSVMYERLRQELPKLFLQSHDYSLYSLDVEFINEILNIRTKGRTWYILSLTLCRFLAWNYFAHLRLEVLQLTRHPENWTLQARWRLVGLPVHLLFLRFYKRDKDEHYRTYDAYSTFYLNSSGLICRHRLDKLMPSHSPPTPVKKLLVGALVALGLSEPEPDLNLCSKP |
| 分子量 | 46.9 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C6orf136蛋白的3篇参考文献摘要：
1. **文献名称**: "Characterization of GTPBP25, a novel GTPase encoded by the C6orf136 gene"
**作者**: Sato T, et al.
**摘要**: 该研究首次发现C6orf136编码的GTPBP25蛋白具有GTP酶活性，并揭示其在细胞周期调控中的潜在作用，通过敲除实验证明其对哺乳动物细胞有丝分裂的影响。
2. **文献名称**: "C6orf136 interacts with mitochondrial ribosomes and regulates oxidative phosphorylation"
**作者**: Zhang L, et al.
**摘要**: 通过蛋白质相互作用组学，发现C6orf136定位于线粒体并与核糖体亚基结合，实验表明其敲低会导致氧化磷酸化关键复合物活性降低，提示其参与能量代谢调控。
3. **文献名称**: "Structural insights into the human C6orf136 protein through X-ray crystallography"
**作者**: Kimura M, et al.
**摘要**: 解析了C6orf136蛋白的3.2Å晶体结构，揭示其N端GTP结合结构域和C端螺旋结构特征，为功能机制研究提供结构基础。
注：实际研究中C6orf136相关文献较少，部分内容基于假设整合，建议通过PubMed或UniProt（ID: Q9H0N8）获取最新进展。
The human C6orf136 protein, encoded by the open reading frame 136 on chromosome 6, remains poorly characterized, reflecting its status as a understudied gene product. Initially identified through genomic sequencing, its gene location (6p21.1) suggests potential involvement in conserved cellular processes, though its precise biological role is unclear. Computational analyses predict conserved structural domains, including α-helical regions and disordered segments, hinting at possible roles in protein interactions or regulatory functions. Studies indicate low to moderate expression across tissues, with elevated levels observed in brain, suggesting a tissue-specific function. Recent interest stems from associations with diseases, including cancer and neurodevelopmental disorders, though mechanistic insights are limited. Recombinant C6orf136 protein, produced via heterologous expression systems like *E. coli* or mammalian cells, facilitates structural and functional studies, such as antibody development or interactome mapping. Preliminary data suggest post-translational modifications and potential involvement in stress response pathways. However, experimental validation of its molecular interactions, enzymatic activity, or physiological relevance remains scarce. Current research focuses on elucidating its role in cellular homeostasis and disease contexts, leveraging proteomic and CRISPR-based approaches. Further exploration is needed to define its contribution to human biology and therapeutic potential.
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