| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C6orf134 |
| Uniprot No | Q5SQI0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 2-224aa |
| 氨基酸序列 | MSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELGL EFPNLPYYI DGDVKLTQSMAIIRYIADKHNMLGGCPKERAEISMLEGA VLDIRYGVSRIAYSKDFETLK VDFLSKLPEMLKMFEDRLCHKTYLNGD HVTHPDFMLYDALDVVLYMDPMCLDAFPKLV CFKKRIEAIPQIDKYLK SSKYIAWPLQGWQATFGGGDHPPKSDLEVLFQGPLGSWLTW PFCFLTI TLREEGVCHLESVDLQQQIMTIIDELGKASAKAQNLSAPITSASRMQSNR HV VYILKDSSARPAGKGAIIGFIKVGYKKLFVLDDREAHNEVEPLCIL DFYIHESVQRHGHG RELFQYMLQKERVEPHQLAIDRPSQKLLKFLNKH YNLETTVPQVNNFVIFEGFFAHQH RPPAPSLRATRHSRAAAVDPTPAA PARKLPPKRAEGDIKPYS |
| 分子量 | 52 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下关于C6orf134蛋白研究的参考文献摘要（模拟虚构内容，供参考）：
1. **文献名称**: *"C6orf134 encodes a novel DNA repair factor through interaction with PARP1"*
**作者**: Li Y et al. (2021)
**摘要**: 研究发现C6orf134蛋白通过直接结合PARP1调控DNA损伤修复通路，其重组蛋白在体外实验中被证明可增强PARP1的酶活性，提示其在基因组稳定性中的潜在作用。
2. **文献名称**: *"Structural analysis of recombinant human C6orf134 reveals a zinc-binding domain"*
**作者**: Sato K et al. (2019)
**摘要**: 通过重组表达和X射线晶体学解析C6orf134的蛋白结构，发现其含有一个锌离子结合结构域，暗示其可能作为金属酶或参与蛋白质相互作用。
3. **文献名称**: *"C6orf134 promotes cancer cell invasion via NF-κB signaling in glioblastoma"*
**作者**: Chen L et al. (2022)
**摘要**: 重组C6orf134蛋白在胶质母细胞瘤细胞模型中激活NF-κB通路，通过上调MMP9表达促进肿瘤细胞迁移和侵袭，可能成为潜在治疗靶点。
4. **文献名称**: *"Systematic screening of C6orf134 interactions using yeast two-hybrid assay"*
**作者**: Wang H et al. (2020)
**摘要**: 基于重组蛋白的酵母双杂交实验发现，C6orf134与多个线粒体蛋白存在相互作用，提示其可能在细胞能量代谢中发挥作用。
注：以上为示例内容，真实研究需通过 **PubMed/Google Scholar** 检索关键词（如"C6orf134 recombinant"或"HGNC:26876"）获取最新数据。当前已知C6orf134功能尚未完全明确，多篇研究聚焦于其在肿瘤或DNA修复中的机制。
**Background of Human Recombinant C6orf134 Protein**
The C6orf134 gene, located on chromosome 6p21.1, encodes a protein with poorly characterized molecular functions, though it is implicated in diverse cellular processes. This gene, also referred to as C6orf134 or FAM46B, is evolutionarily conserved across vertebrates, suggesting its biological significance. While the exact role of C6orf134 remains unclear, studies associate it with potential involvement in cell proliferation, differentiation, and signaling pathways. Structural predictions indicate the protein may contain disordered regions and a putative transmembrane domain, hinting at interactions with membranes or other biomolecules.
Recombinant human C6orf134 protein is typically generated using expression systems like mammalian cells or *E. coli* to ensure proper folding and post-translational modifications. Its recombinant form enables functional studies, antibody production, and interaction assays. Limited research links C6orf134 to diseases; for example, altered expression has been observed in cancers and autoimmune disorders, though causal mechanisms are undefined. Challenges in studying C6orf134 include its low abundance, lack of validated substrates, and absence of well-established cellular or animal models. Current efforts focus on elucidating its interactome, enzymatic activity (if any), and regulatory roles in stress responses or immune modulation. Further characterization of recombinant C6orf134 may clarify its physiological relevance and therapeutic potential in human pathologies.
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