| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C6orf118 |
| Uniprot No | Q5T5N4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-469aa |
| 氨基酸序列 | MAEEREPELY LKWKHCETPG VKTLCNLKHC ETPGVKTLCN LKKLLNRLQK DHREDVYLYI SGHLNPNKLY QPPETILQHW PNAHRPKGER ASEVGEPPAG KVARMKEALA HFTIHTALVP SEAQDTPLFR YLNPQASLSH TSEEDFLPVE AVREGKEEKK GGPPGRGPPG WRRREELRLP DLKVLCYQEA GSRGTRDRHH YVSSYLAGAT SADRYRMFLR FQKEVLAKQD LLKNDFTGSK AAAGHERKLQ QELQKICTCS PQQFNRLHVF GKVFEDICNS SLIFGDLLKK VKDEYELYMA TLLESQPAAQ YEALLAQLKA LGQRPVKTAD MDLAREELRM LVTATKAALE QNDRLRSELE MEVALLQSAK ERSESSEKHI IDENRLTLTE KVEKKRCEIL SKWDEIQALE KEIKTTLVHT GISDITENRI KSIEHEAIQL ETENMILKKK IKGPLEIYQG ICKIRGNRR |
| 分子量 | 80.2 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C6orf118蛋白的示例性参考文献（注：以下内容为模拟生成，具体文献需根据实际研究查询）：
1. **标题**: *"Characterization of C6orf118 Protein and Its Role in Cellular Stress Response"*
**作者**: Smith A, et al.
**摘要**: 通过体外实验发现C6orf118蛋白定位于细胞核，在DNA损伤应激条件下表达上调，可能参与修复通路调控。
2. **标题**: *"Structural Analysis of C6orf118 Reveals a Novel Zinc-Binding Domain"*
**作者**: Lee J, Wang Y.
**摘要**: 利用X射线晶体学解析C6orf118蛋白的三维结构，发现其具有锌离子结合位点，推测可能参与金属依赖性酶活性。
3. **标题**: *"C6orf118 Gene Knockout Mice Exhibit Impaired Neuronal Development"*
**作者**: Tanaka R, et al.
**摘要**: 构建C6orf118基因敲除小鼠模型，观察到小鼠大脑皮层神经元迁移异常，提示该蛋白在神经发育中的潜在作用。
4. **标题**: *"Bioinformatic and Expression Profiling of C6orf118 Across Human Tissues"*
**作者**: Chen L, et al.
**摘要**: 通过生物信息学分析结合RNA-seq数据，发现C6orf118在睾丸和脑组织中高表达，可能与生殖及神经系统功能相关。
**提示**：以上为示例文献框架，实际研究需通过PubMed、Google Scholar等数据库检索关键词（如"C6orf118 protein"或"chromosome 6 open reading frame 118"），并筛选近年发表的高影响力论文。部分研究可能以别称（如“NXPH4”或“neurexophilin 4”）发表。
**Background of Human C6orf118 Protein**
The human C6orf118 protein, encoded by the *C6orf118* gene (Chromosome 6 Open Reading Frame 118), is a poorly characterized protein located on chromosome 6p21.33. This region is notable for its association with immune-related genes and disease susceptibility loci, including the major histocompatibility complex (MHC). C6orf118 is predicted to encode a multi-exon transcript, with conserved orthologs identified across vertebrates, suggesting functional importance.
Structurally, C6orf118 is annotated as a putative intracellular protein, though its precise domain architecture remains unclear. Limited functional studies suggest potential roles in transcriptional regulation, DNA repair, or cell cycle control, possibly mediated through interactions with other regulatory proteins.
Disease associations are emerging but not yet definitive. Variants near *C6orf118* have been linked to autoimmune disorders, cancers, and neurodegenerative diseases in genome-wide association studies (GWAS), though causative mechanisms are unverified. Some evidence implicates its dysregulation in tumor progression, such as glioblastoma, hinting at oncogenic or tumor-suppressive potential.
Current research gaps include incomplete understanding of its biochemical properties, signaling pathways, and physiological substrates. Further studies involving structural analysis, tissue-specific expression profiling, and knockout models are critical to unravel its molecular functions and therapeutic relevance.
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