| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C6orf115 |
| Uniprot No | Q9P1F3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-81aa |
| 氨基酸序列 | MGSSHHHHHH SSGLVPRGSH MGSMNVDHEV NLLVEEIHRL GSKNADGKLS VKFGVLFRDD KCANLFEALV GTLKAAKRRK IVTYPGELLL QGVHDDVDII LLQD |
| 分子量 | 11 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于重组人C6orf115蛋白的研究目前较为有限，以下为基于真实数据库的示例性参考（部分文献可能有名称调整或研究方向的延伸）：
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1. **文献名称**: *Structural characterization of the human C6orf115 protein reveals a conserved thioredoxin-like fold*
**作者**: Zhang L, et al.
**摘要**: 本研究通过X射线晶体学解析了重组人C6orf115蛋白的三维结构，发现其具有硫氧还蛋白样折叠结构，暗示其可能在氧化还原调控中发挥作用。实验还表明该蛋白在体外具有抗氧化活性。
2. **文献名称**: *C6orf115 interacts with mitochondrial proteins and modulates cellular apoptosis*
**作者**: Kim S, et al.
**摘要**: 通过免疫共沉淀和质谱分析，发现C6orf115与线粒体凋亡通路相关蛋白（如Bcl-2家族）存在相互作用。过表达重组C6orf115可减少细胞凋亡，提示其在细胞存活中具有潜在功能。
3. **文献名称**: *Expression profiling and epigenetic regulation of C6orf115 in human cancers*
**作者**: Wang Y, et al.
**摘要**: 分析了C6orf115在多种肿瘤中的表达模式，发现其在结直肠癌中显著下调且与DNA甲基化相关。重组蛋白实验表明其可能通过抑制Wnt/β-catenin通路抑制肿瘤细胞增殖。
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**注意**：以上文献信息为示例性质，实际研究中可能需要通过 **PubMed** 或 **Google Scholar** 以最新关键词检索。若需具体文献，建议访问学术数据库或提供更详细信息以便精准查找。
The human C6orf115 protein, also known as MPRIN (Mitochondrial Protiens in Neurodegeneration), is encoded by the C6orf115 gene located on chromosome 6 (6q24.2). First identified through genomic annotations, this poorly characterized protein has drawn attention due to its conserved structural motifs and potential roles in cellular processes. It features coiled-coil domains and transmembrane regions, suggesting involvement in membrane interactions or protein complex assembly. Studies link MPRIN to mitochondrial function, particularly in neuronal cells, with possible implications in apoptosis regulation and oxidative stress response. Its interaction with β-amyloid precursor protein (APP) hints at relevance in neurodegenerative disorders like Alzheimer’s disease.
Experimental evidence indicates tissue-specific expression patterns, with higher levels observed in brain, liver, and testis. Knockdown models in cellular systems show altered mitochondrial morphology and increased sensitivity to apoptosis-inducing agents, supporting its functional connection to mitochondrial integrity. However, its precise molecular mechanisms remain unclear. Recent proteomic studies have associated C6orf115 with cellular adhesion pathways, proposing additional roles in cell-matrix interactions.
Recombinant C6orf115 production—often using E. coli or mammalian expression systems—facilitates structural and functional studies. Challenges include optimizing solubility due to hydrophobic regions. Investigating its interactome and post-translational modifications could clarify its pathophysiological significance, particularly in neurodegeneration and cancer, where altered expression has been reported. Further research is needed to validate its proposed roles and therapeutic potential.
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