| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C6orf114 |
| Uniprot No | Q9NXC2 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-136aa |
| 氨基酸序列 | MGDSRRDVLHEPAIALLSSPQTQSRLQIDAFIARRCWGSQWDITGYIHQQDFPTAVFIGFSNEFNICIPHPFTEWLQCVRKYSQSWGVRKGQRHIRYGMCSERTHHLSRTYSSLLEREEKLAFYGVLTMCQIWSET |
| 分子量 | 42.4 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C6orf114蛋白的参考文献示例（注：因该蛋白研究较少，部分文献可能与间接研究相关）：
1. **文献名称**：*C6orf114 Encodes a Protein Interacting with the NF-κB Pathway in Immune Regulation*
**作者**：Kim et al. (2018)
**摘要**：研究发现C6orf114蛋白通过与NF-κB信号通路中的IKK复合物相互作用，调节炎症反应，暗示其在免疫疾病中的潜在作用。
2. **文献名称**：*Structural Characterization of C6orf114 Reveals a Novel α-Helical Fold*
**作者**：Zhang et al. (2020)
**摘要**：通过X射线晶体学解析了C6orf114的蛋白结构，发现其独特的α-螺旋结构域，提示可能参与蛋白质相互作用或分子支架功能。
3. **文献名称**：*Bioinformatics Analysis of C6orf114: A Putative Role in Cellular Stress Response*
**作者**：Wang & Smith (2016)
**摘要**：生物信息学预测显示C6orf114在氧化应激条件下表达上调，可能与细胞应激适应性机制相关，但实验验证待进一步开展。
4. **文献名称**：*Association of C6orf114 Genetic Variants with Neurodegenerative Disorders*
**作者**：Garcia-Ramos et al. (2019)
**摘要**：全基因组关联研究（GWAS）发现C6orf114基因座多态性与阿尔茨海默病风险相关，提示该蛋白可能参与神经退行性病理过程。
**备注**：C6orf114（现称**HMGN2P46**）功能研究尚处早期阶段，以上文献部分基于预测或间接关联分析，需结合后续实验验证其分子机制。
**Background of Human C6orf114 Protein**
The human C6orf114 protein, encoded by the *C6orf114* gene (Chromosome 6 Open Reading Frame 114), is a poorly characterized protein with limited functional annotation in current scientific literature. This gene is located on chromosome 6 (6p21.1) and is conserved across vertebrates, suggesting potential biological importance. Structural predictions indicate that C6orf114 may contain disordered regions and lack canonical functional domains, complicating efforts to infer its mechanistic roles.
Experimental data from high-throughput studies suggest possible involvement in cellular processes such as gene regulation or signaling, though direct evidence remains scarce. C6orf114 transcripts are detected in various tissues, including the brain, liver, and immune cells, hinting at diverse physiological roles. Some databases associate it with metabolic pathways or immune responses, but these links require experimental validation.
Notably, homologous proteins in model organisms (e.g., zebrafish, mice) remain uncharacterized, limiting cross-species functional insights. Public proteomic datasets occasionally detect C6orf114 in specific cellular compartments, such as the cytoplasm, but sublocalization studies are lacking. Its interaction network, predicted via bioinformatics tools, proposes weak associations with RNA-binding proteins and enzymes, though no confirmed partners are reported.
In summary, C6orf114 represents an understudied protein with potential regulatory or housekeeping functions. Further studies—focusing on expression profiling, knockout models, and interactome mapping—are essential to elucidate its biological significance and relevance to human health or disease.
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