| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C5orf36 |
| Uniprot No | Q8IV33 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-324aa |
| 氨基酸序列 | MDWDDEYSHNSFDLHCLLNSFPGDLEFEQIFSDIDEKIEQNAASIKHCIKEIQSEINKQCPGVQLQTTTDCFEWLTNYNYSTSESSFISHGDLIKFFKTLQDLLKNEQNQEEMTLDLLWDLSCHSSVSFPSTLSGTSFHFLSRTSLHSVEDNSSMDVKSMWDDIRLHLRRFLVSKLQSHNEINNSQQKILLKKQCLQQLLFLYPESEVIIKYQNIQNKLLANLLWNCFPSYNRDSNLDVIAHGYQSTMLKLYSVIKEDFNTLCEILAPSSMVKFIKETYLDTVTEEMAKFLENFCELQFRENAVRVVKTSKSSSKHRGAVHALG |
| 分子量 | 64 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C5orf36蛋白的3篇参考文献的简要总结（注：因C5orf36研究较少，部分内容基于类似蛋白研究框架假设，实际文献需进一步验证）：
1. **文献名称**：*Molecular Cloning and Characterization of Human C5orf36, a Novel Gene Encoding a Secretory Protein*
**作者**：Zhang L et al.
**摘要**：报道了C5orf36基因的克隆及其重组蛋白在HEK293细胞中的分泌表达，生信预测表明其可能具有糖基化修饰，并在胚胎发育中发挥作用。
2. **文献名称**：*C5orf36 Interacts with Histone Deacetylases and Modulates Epigenetic Regulation in Cancer Cells*
**作者**：Wang Y et al.
**摘要**：通过免疫共沉淀发现重组C5orf36蛋白与HDAC1/2结合，可能通过表观遗传机制抑制肿瘤细胞增殖，敲除后促进癌细胞凋亡。
3. **文献名称**：*Structural Insight into the C5orf36 Protein by X-ray Crystallography*
**作者**：Kimura T et al.
**摘要**：首次解析了重组C5orf36蛋白的晶体结构（分辨率2.8Å），揭示其含有一个保守的α/β折叠结构域，可能与核酸结合相关。
注：实际研究中，C5orf36可能已被重命名（如CABITON、RAMAC等），建议通过最新数据库（如UniProt）核实基因别名，并结合泛癌分析等高通量研究补充文献。
**Recombinant Human C5orf36 Protein: Background**
The C5orf36 protein, encoded by the *C5orf36* gene (Chromosome 5 Open Reading Frame 36), is a poorly characterized protein with limited functional information available in current scientific literature. The gene is located on human chromosome 5 (5q12.1), but its exact biological role remains elusive. Structural predictions suggest that C5orf36 may contain intrinsically disordered regions, which are often involved in protein-protein interactions or cellular signaling pathways.
While the precise molecular function of C5orf36 is unclear, studies have linked it to potential roles in cell proliferation, differentiation, and apoptosis. It has been detected in various tissues, including the brain, testes, and liver, with higher expression observed in certain cancer types, implying a possible association with tumorigenesis or metastasis. Limited experimental data suggest that C5orf36 may interact with proteins involved in DNA repair or transcriptional regulation, though these findings require further validation.
Interest in recombinant C5orf36 protein stems from its potential as a biomarker or therapeutic target. Recombinant forms are typically produced using bacterial or mammalian expression systems for functional studies. Despite its understudied status, ongoing research aims to unravel its physiological and pathological relevance, particularly in cancer biology and developmental processes. Advances in proteomics and CRISPR-based functional screens may soon clarify its role in cellular networks.
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