| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C4orf49 |
| Uniprot No | Q8TDB4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-240aa |
| 氨基酸序列 | MYLRRAVSKTLALPLRAPPNPAPLGKDASLRRMSSNRFPGSSGSNMIYYLVVGVTVSAGGYYAYKTVTSDQAKHTEHKTNLKEKTKAEIHPFQGEKENVAETEKASSEAPEELIVEAEVVDAEESPSATVVVIKEASACPGHVEAAPETTAVSAETGPEVTDAAARETTEVNPETTPEVTNAALDEAVTIDNDKDTTKNETSDEYAELEEENSPAESESSAGDDLQEEASVGSEAASAQG |
| 分子量 | 52.8 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为模拟示例（非真实文献，仅供参考格式）：
1. **"Functional characterization of recombinant human C4orf49 protein"**
Smith et al., 2021
摘要：首次报道C4orf49的重组表达及功能，发现其在体外具有ATP酶活性，并参与线粒体能量代谢调控。
2. **"C4orf49 interacts with mTOR signaling pathway in cancer cells"**
Zhang et al., 2019
摘要：通过免疫共沉淀实验，证明重组C4orf49与mTOR复合物存在相互作用，可能影响肿瘤细胞增殖。
3. **"Structural analysis of C4orf49 using X-ray crystallography"**
Brown et al., 2020
摘要：解析了重组C4orf49的晶体结构，揭示其N端结构域具有新型折叠模式，为功能研究提供结构基础。
4. **"Role of C4orf49 in inflammatory response"**
Lee et al., 2018
摘要：利用重组蛋白验证C4orf49在巨噬细胞中的表达，发现其敲除可降低IL-6分泌，提示其参与炎症调控。
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**备注**：C4orf49研究相对较少，实际文献需通过PubMed/Google Scholar检索。推荐使用关键词：`"C4orf49 protein"`、`"recombinant C4orf49"`。如需真实文献辅助，可进一步说明！
**Background of Recombinant Human C4orf49 Protein**
The C4orf49 (Chromosome 4 Open Reading Frame 49) protein is a poorly characterized human protein encoded by the *C4orf49* gene, located on chromosome 4. Its exact biological function remains unclear, though bioinformatic analyses suggest it may play roles in cellular processes such as metabolism, immune regulation, or cell cycle control. Structural predictions indicate it contains potential transmembrane domains and phosphorylation sites, hinting at involvement in signaling pathways.
Recombinant human C4orf49 protein is artificially produced using expression systems (e.g., *E. coli* or mammalian cells) for functional studies. Research has linked *C4orf49* to diseases, including cancer, where its expression varies in tumors compared to normal tissues. For instance, it is downregulated in some carcinomas but upregulated in others, suggesting context-dependent roles. Additionally, studies associate *C4orf49* with neurodegenerative and metabolic disorders, though mechanisms remain unverified.
Despite limited data, C4orf49 homologs in other mammals suggest evolutionary conservation, implying fundamental biological importance. Current research focuses on elucidating its interactors, post-translational modifications, and pathways. Recombinant C4orf49 serves as a critical tool for antibody development, binding assays, and structural analysis, paving the way for uncovering its physiological and pathological significance. Further studies are needed to validate hypotheses and explore therapeutic potential.
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