| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C4orf39 |
| Uniprot No | Q96MZ4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-157aa |
| 氨基酸序列 | MEGCAVRRGSCPLLPGPSAWRASPAGWAGRAKLRSWCRASGLPNRPYTLTGGRHGSVSLLRHPGTTTFVQQRSLHQSWEKRIVFSACPVSRSWCPERNFSGSIPAVTPPKLPGHSKSEGPPGKVRKRTTIRSQPLFVTRTRGFGSAVGWLPLGSPVL |
| 分子量 | 43.4 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C4orf39蛋白的假设性参考文献示例，内容基于常见的相关研究方向构建：
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1. **文献名称**：**"Molecular Cloning and Characterization of Human C4orf39 as a Novel Stress-Responsive Protein"**
**作者**：Zhang Y, et al.
**摘要**：本研究首次克隆并鉴定了人类C4orf39基因，证实其编码的蛋白质定位于细胞核内。重组表达的C4orf39在氧化应激条件下显著上调，提示其可能在细胞应激反应中发挥调控作用。
2. **文献名称**：**"C4orf39 Interacts with DNA Repair Complexes and Modulates Genomic Stability"**
**作者**：Smith JL, et al.
**摘要**：通过免疫共沉淀和质谱分析，发现C4orf39与BRCA1/2复合物相互作用，可能参与DNA损伤修复过程。敲低C4orf39导致细胞对电离辐射敏感性增加，表明其在维持基因组稳定性中的关键功能。
3. **文献名称**：**"Dysregulation of C4orf39 Expression in Hepatocellular Carcinoma and Its Prognostic Implications"**
**作者**：Li H, et al.
**摘要**：该研究分析了C4orf39在肝癌组织中的表达水平，发现其表达显著低于癌旁组织，且低表达与患者预后不良相关。体外实验表明，过表达C4orf39可抑制肝癌细胞增殖和迁移。
4. **文献名称**：**"Structural Insights into C4orf39 Reveal a Conserved Role in Mitochondrial Function"**
**作者**：Wang T, et al.
**摘要**：通过晶体学解析了C4orf39的蛋白结构，揭示其含有保守的跨膜结构域。功能研究表明，C4orf39定位于线粒体内膜，可能通过调控电子传递链影响能量代谢。
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*注：以上文献及内容均为假设性示例，实际引用时需以真实发表的论文为准。*
C4orf39 (Chromosome 4 Open Reading Frame 39) is a relatively uncharacterized human protein encoded by the C4orf39 gene located on chromosome 4 (4q32.1). Initially identified through genomic sequencing, its biological function remains poorly understood. The protein is predicted to contain 198 amino acids, with a molecular weight of approximately 22 kDa, and exhibits structural features such as a conserved N-terminal domain of unknown function (DUF4565) and potential phosphorylation sites, suggesting regulatory roles. Limited studies indicate its possible involvement in cellular processes related to reproduction, as it shows enriched expression in testicular tissues. Some evidence links C4orf39 to cilia-related functions or gametogenesis, though mechanistic details are unclear. Bioinformatics analyses propose interactions with proteins associated with ubiquitination pathways, implying a role in protein degradation or signaling. Currently, no direct association with specific diseases has been confirmed, though altered expression patterns have been observed in certain cancers and neurodegenerative conditions. Research on C4orf39 remains preliminary, with most data derived from high-throughput studies or computational predictions. Further experimental validation is required to elucidate its physiological significance, molecular interactions, and potential clinical relevance. Its conserved presence across vertebrates suggests evolutionary importance, warranting deeper investigation into its cellular localization and functional pathways.
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