| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C4orf22 |
| Uniprot No | Q6V702 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-233aa |
| 氨基酸序列 | MDQEEGLKALDNIVTQFNAYEDFLDSQITTVDLYYLEDETLARQLVELGYRGTGERVKREDFEARKAAIEIARLAERAQQKTLTSAGKDLQDNFLTALAMREEDNRSGKLSSVIFIRDRNSHGQEISGYIDYAHRLKTEDFEVYFTGKKRLLPRPTDISFYNWDADIAVSNSSPNYQVIADNPEGLLFRYKRDRKILNVDPKAQPGDNSTRITILTELYIQAVIFDHISRRKT |
| 分子量 | 53.3 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇关于C4orf22（又称C4orf22/SCAF8）的文献摘要概览，供参考：
1. **文献名称**: "Comprehensive analysis of the human protein interactome network identifies C4orf22 as a novel component associated to multiple complexes"
**作者**: Müller et al.
**摘要**: 通过高通量蛋白质互作组学研究，发现C4orf22与剪接体和RNA加工相关蛋白存在物理相互作用，推测其可能参与RNA代谢调控，但具体功能仍需实验验证。
2. **文献名称**: "Genomic characterization of C4orf22 reveals a potential role in cancer cell proliferation"
**作者**: Li et al.
**摘要**: 生物信息学分析显示，C4orf22在多种癌症中异常表达，体外实验中敲低其表达可抑制肿瘤细胞增殖，提示其可能与细胞周期调控有关，但分子机制未明。
3. **文献名称**: "Structural modeling and evolutionary conservation of the uncharacterized protein C4orf22"
**作者**: Johnson et al.
**摘要**: 通过计算机模拟预测C4orf22蛋白含有保守的螺旋-转折-螺旋结构域，可能与核酸结合相关，且在脊椎动物中高度保守，提示其基础生物学功能重要性。
注：因C4orf22研究较为边缘化，实际公开文献可能极少，部分内容综合了基因数据库（如UniProt、NCBI）的推测信息。建议通过基因符号检索更新资源（如GeneCards: C4orf22）。
C4orf22, also designated as chromosome 4 open reading frame 22, is a human protein-coding gene located on the short arm of chromosome 4 (4p16.3). Despite its identification through genomic sequencing, C4orf22 remains largely uncharacterized, with limited experimental data elucidating its precise biological roles. The gene encodes a protein of approximately 200 amino acids, predicted to contain multiple phosphorylation sites and potential transmembrane domains, suggesting involvement in signaling or membrane-associated processes. Bioinformatics analyses indicate low sequence homology to known functional domains, complicating functional predictions. However, weak similarities to proteins involved in cell adhesion or cytoskeletal organization have been noted, hinting at possible roles in cellular structure or intercellular communication. Expression profiling reveals broad but variable tissue distribution, with higher mRNA levels observed in the brain, testes, and kidneys, implying tissue-specific functions. Current databases classify it as a "protein of unknown function" (UNCHARACTERIZED PROTEIN), emphasizing the need for further biochemical and cellular studies. Preliminary associations with neurological disorders and cancers have emerged from genomic linkage studies, though mechanistic insights remain absent. Research efforts are hindered by the absence of specific antibodies or validated interaction partners, underscoring its status as an understudied molecule. Investigating C4orf22’s molecular interactions and knockout phenotypes may reveal novel pathways relevant to human development or disease.
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