| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C4orf19 |
| Uniprot No | Q8IY42 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-314aa |
| 氨基酸序列 | MGCRCCKIIQSYLFDPVQVPSPGYVNEVNSCKLDEDDTDKLKGKWSSEVLVQKNDPQRQGSKKTESSSRTADPWEPCWPHQGPLPQGDAGGEHHACGVNGIGPAATPQPTGNSSPTQDDRGSWASTANTVPPTQPFLEGGGTRKQDCVLLASEGTQVMRNGDSRAPSEAESFALEVQDHVFQIPAPDYLQHWGPAGDNVDHNEKDCVFKNHTEDESLEGIQPPVGEHGLNTPFSVRRSWDSLNEDVETEVLSICFNEKGPVHAMPVVDSGNRQEDTHGSDGDGDGEIVDEDAAVAEALAALEAATAGEDLDETD |
| 分子量 | 60.1 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C4orf19蛋白的假设性参考文献示例（注意：C4orf19相关研究较少，以下内容为虚构示例，仅作参考）：
1. **标题**：*C4orf19蛋白的功能鉴定：一种新型细胞增殖调控因子*
**作者**：Smith A, et al.
**摘要**：研究发现C4orf19在哺乳动物细胞中高表达，通过RNA干扰敲低后抑制细胞周期进程，提示其可能通过调控周期蛋白依赖性激酶（CDKs）参与细胞增殖。
2. **标题**：*C4orf19与内源性逆转录病毒元件的进化关联*
**作者**：Zhang L, et al.
**摘要**：生信分析揭示C4orf19（ERVMER34-1）与人类内源性逆转录病毒序列同源，可能通过进化获得免疫调节功能，并在胎盘发育中发挥作用。
3. **标题**：*C4orf19在肿瘤中的表达谱及其临床意义*
**作者**：Wang X, et al.
**摘要**：通过组织芯片分析发现，C4orf19在乳腺癌中表达显著上调，且高表达与患者预后不良相关，可能作为潜在肿瘤标志物。
4. **标题**：*C4orf19蛋白的晶体结构解析及其底物结合特性*
**作者**：Chen Y, et al.
**摘要**：首次报道C4orf19的X射线晶体结构，揭示其具有类似水解酶的活性位点，体外实验证实其可降解特定脂类分子。
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**备注**：真实文献可能极为有限，建议通过PubMed或Google Scholar以“C4orf19”或“ERVMER34-1”为关键词检索最新研究。部分研究可能以预印本或未更名形式发表。
Recombinant human C4orf19 protein, derived from the chromosome 4 open reading frame 19 gene (C4orf19), represents a relatively understudied protein in human biology. The C4orf19 gene is located on the short arm of chromosome 4 (4p16.3) and encodes a protein with a predicted molecular weight of approximately 30-35 kDa. While its exact biological function remains unclear, computational analyses suggest it may contain conserved structural motifs indicative of roles in protein-protein interactions or enzymatic processes. Limited experimental studies have associated C4orf19 with cellular stress responses, though validation of these findings remains pending.
Interest in recombinant C4orf19 protein production has emerged to enable functional characterization, antibody development, and structural studies. The recombinant form is typically expressed in model systems like *E. coli* or mammalian cell cultures, allowing purification for biochemical assays. Preliminary data hint at possible involvement in pathways related to cell cycle regulation or nucleic acid metabolism, but mechanistic insights are lacking. Its expression pattern appears tissue-specific, with higher mRNA levels detected in brain and testis tissues.
Despite being classified as a "protein of unknown function" in major databases, recent proteomic studies have identified C4orf19 interactions with proteins linked to ubiquitination and RNA processing, suggesting potential roles in post-translational modification systems. Research on this protein may contribute to understanding rare genetic disorders linked to chromosome 4 abnormalities. Current challenges include clarifying its subcellular localization and identifying physiological substrates or binding partners using recombinant variants.
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