| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C4orf14 |
| Uniprot No | Q8NC60 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-698aa |
| 氨基酸序列 | MLPARLPFRLLSLFLRGSAPTAARHGLREPLLERRCAAASSFQHSSSLGRELPYDPVDTEGFGEGGDMQERFLFPEYILDPEPQPTREKQLQELQQQQEEEERQRQQRREERRQQNLRARSREHPVVGHPDPALPPSGVNCSGCGAELHCQDAGVPGYLPREKFLRTAEADGGLARTVCQRCWLLSHHRRALRLQVSREQYLELVSAALRRPGPSLVLYMVDLLDLPDALLPDLPALVGPKQLIVLGNKVDLLPQDAPGYRQRLRERLWEDCARAGLLLAPGHQGPQRPVKDEPQDGENPNPPNWSRTVVRDVRLISAKTGYGVEELISALQRSWRYRGDVYLVGATNAGKSTLFNTLLESDYCTAKGSEAIDRATISPWPGTTLNLLKFPICNPTPYRMFKRHQRLKKDSTQAEEDLSEQEQNQLNVLKKHGYVVGRVGRTFLYSEEQKDNIPFEFDADSLAFDMENDPVMGTHKSTKQVELTAQDVKDAHWFYDTPGITKENCILNLLTEKEVNIVLPTQSIVPRTFVLKPGMVLFLGAIGRIDFLQGNQSAWFTVVASNILPVHITSLDRADALYQKHAGHTLLQIPMGGKERMAGFPPLVAEDIMLKEGLGASEAVADIKFSSAGWVSVTPNFKDRLHLRGYTPEGTVLTVRPPLLPYIVNIKGQRIKKSVAYKTKKPPSLMYNVRKKKGKINV |
| 分子量 | 103.18 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为3篇关于重组人C4orf14蛋白的示例参考文献（注：文献为虚构示例，仅供格式参考）：
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1. **文献名称**: *"Functional Characterization of C4orf14 in Cell Proliferation and Apoptosis"*
**作者**: Zhang L. et al.
**摘要**: 该研究通过基因沉默实验发现，C4orf14通过调控MAPK信号通路影响肿瘤细胞的增殖和凋亡，提示其潜在抗癌作用。
2. **文献名称**: *"Structural Insights into the C4orf14 Protein and Its Interaction with RNA"*
**作者**: Smith J.R. et al.
**摘要**: 通过X射线晶体学首次解析了C4orf14的蛋白结构，揭示其N端存在RNA结合域，可能在RNA稳定性中发挥作用。
3. **文献名称**: *"C4orf14 as a Novel Biomarker in Neurodevelopmental Disorders"*
**作者**: Gupta S. et al.
**摘要**: 在小鼠模型中证实C4orf14表达缺失导致神经元迁移异常，提示其与自闭症等神经发育疾病相关。
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（注：实际研究中请通过PubMed、Google Scholar等数据库搜索真实文献。）
**Background of Human C4orf14 Protein**
C4orf14 (Chromosome 4 Open Reading Frame 14) is a poorly characterized protein encoded by the *C4orf14* gene located on human chromosome 4 (4q31.21). Despite limited functional annotation, bioinformatic analyses suggest it contains conserved structural domains, including putative coiled-coil regions and nuclear localization signals, implying potential roles in protein interactions or nuclear processes. The protein is ubiquitously expressed across tissues, with higher levels observed in the testis, brain, and kidneys, hinting at tissue-specific functions.
Current studies link C4orf14 to diverse cellular processes. It interacts with TRIM28, a transcriptional regulator involved in epigenetic silencing, suggesting a possible role in chromatin remodeling or gene expression. Additionally, C4orf14 has been implicated in cell cycle regulation, as its knockdown disrupts mitotic progression. Emerging evidence also associates *C4orf14* variants with diseases, including cancer (e.g., hepatocellular carcinoma) and neurodevelopmental disorders, though mechanistic insights remain scarce.
Despite its enigmatic nature, C4orf14’s conserved sequence across vertebrates underscores evolutionary significance. Further research is needed to elucidate its molecular mechanisms, interactome, and therapeutic potential. Advances in proteomics and CRISPR-based functional genomics may accelerate uncovering its role in health and disease.
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