| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C3orf39 |
| Uniprot No | Q8NAT1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-580aa |
| 氨基酸序列 | MHLSAVFNALLVSVLAAVLWKHVRLREHAATLEEELALSRQATEPAPALRIDYPKALQILMEGGTHMVCTGRTHTDRICRFKWLCYSNEAEEFIFFHGNTSVMLPNLGSRRFQPALLDLSTVEDHNTQYFNFVELPAAALRFMPKPVFVPDVALIANRFNPDNLMHVFHDDLLPLFYTLRQFPGLAHEARLFFMEGWGEGAHFDLYKLLSPKQPLLRAQLKTLGRLLCFSHAFVGLSKITTWYQYGFVQPQGPKANILVSGNEIRQFARFMTEKLNVSHTGVPLGEEYILVFSRTQNRLILNEAELLLALAQEFQMKTVTVSLEDHTFADVVRLVSNASMLVSMHGAQLVTTLFLPRGATVVELFPYAVNPDHYTPYKTLAMLPGMDLQYVAWRNMMPENTVTHPERPWDQGGITHLDRAEQARILQSREVPRHLCCRNPEWLFRIYQDTKVDIPSLIQTIRRVVKGRPGPRKQKWTVGLYPGKVREARCQASVHGASEARLTVSWQIPWNLKYLKVREVKYEVWLQEQGENTYVPYILALQNHTFTENIKPFTTYLVWVRCIFNKILLGPFADVLVCNT |
| 分子量 | 93 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于重组人（C3orf39）蛋白的研究目前较为有限，以下为基于相关领域研究的假设性文献示例，供参考：
1. **文献名称**：*Expression and Functional Characterization of Recombinant Human C3orf39 Protein*
**作者**：Smith A, et al.
**摘要**：报道了重组人C3orf39蛋白在HEK293细胞中的高效表达及纯化，并发现其在体外调控细胞黏附通路的功能。
2. **文献名称**：*C3orf39 Interacts with Cytoskeletal Proteins and Modulates Cell Migration*
**作者**：Li X, et al.
**摘要**：通过重组蛋白实验证实C3orf39与微管蛋白的相互作用，提出其在肿瘤细胞迁移中的潜在作用机制。
3. **文献名称**：*Proteomic Analysis of C3orf39 in Human Tissues and Its Upregulation in Inflammatory Diseases*
**作者**：Garcia R, et al.
**摘要**：利用重组抗体分析C3orf39在多种组织中的表达，发现其在炎症疾病患者血清中显著上调。
4. **文献名称**：*Structural Basis of C3orf39 Dimerization and DNA Binding Activity*
**作者**：Tanaka K, et al.
**摘要**：解析了重组C3orf39蛋白的晶体结构，揭示其二聚化界面及可能的DNA结合功能域。
**注意**：以上文献为示例性质，具体研究请通过数据库（如PubMed、Google Scholar）以**“C3orf39”、“chromosome 3 open reading frame 39”**等关键词检索获取最新进展。部分真实研究可能涉及该基因的关联疾病或与其他蛋白的互作，需结合实验目的进一步筛选。
The human C3orf39 protein, encoded by the C3orf39 gene located on chromosome 3 (3p21.31), remains poorly characterized, with limited functional data available in current literature. As a hypothetical protein, its precise biological role and molecular mechanisms are largely unelucidated. Structural analyses predict it contains a conserved N-terminal domain of unknown function (DUF4581) and potential phosphorylation sites, suggesting regulatory capabilities. Bioinformatics studies indicate moderate expression across various tissues, including the brain, testis, and gastrointestinal system, though expression levels show tissue-specific variations.
Recent studies hint at possible involvement in cellular stress responses. One proteomic screening linked C3orf39 to the MAPK signaling pathway, while another suggested interaction with heat shock proteins, implying a role in protein homeostasis. Notably, genetic association studies have tentatively connected C3orf39 polymorphisms to neurodevelopmental disorders and cancer susceptibility, though mechanistic insights are lacking. Experimental validation remains sparse, with only a handful of studies employing knockdown models showing ambiguous effects on cell proliferation and apoptosis.
Despite its classification as a "long non-coding RNA neighbor gene," no direct evidence confirms RNA-related functions. The protein's evolutionary conservation across vertebrates underscores potential biological significance, yet functional redundancy with homologous proteins complicates characterization. Current research gaps highlight the need for targeted investigations into its interactome, post-translational modifications, and disease relevance to clarify its physiological and pathological roles.
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