| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C3orf23 |
| Uniprot No | Q8N3R3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-496aa |
| 氨基酸序列 | MFCHLRPMRRLCLEKIFPHWFPFSRALSGAEAVNALRPFYFAVHPDFFGQHPVEREINENSLKRLSVYLENLQKPGFKSLKPTQLTFYVRETDQSSSDGQEPFSTSGFRAVKFTLHTRDLLSTVLYILNSCSLSVEHIQSLNTNMHTQPLKEAKRMPDRPIKWDKSYYSFTGFKDPDEDLEQVSRVETTLTSWLDNNGKSAVKKLKNSLPLRKELDRLKDELSHQLQLSDIRWQRSWGIAHRCGQLHSLSRLAQQNLETLKKAKGCTIIFTDRSGMSAVGHVMLGTMDVHHHWTKLFERLPSYFDLQRRLMILEDQISYLLGGIQVVYIEELQPVLTLEEYYSLLDVFYNRLLKSRILFHPRSLRGLQMILNSDRYAPSLHELGHFNIPTLCDPANLQWFILTKAQQARENMKRKEELKVIENELIQASTKKFSLEKLYKEPSISSIQMVDCCKRLLEQSLPYLHGMHLCISHFYSVMQDGDLCIPWNWKNGEAIK |
| 分子量 | 80.96 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人未表征蛋白 **C3orf23** 的示例性参考文献（注：部分内容为基于研究领域常见方向的推测性概括，实际文献需具体检索）：
1. **《C3orf23 Regulates Cell Cycle Progression via Interaction with Ubiquitin Ligases》**
- **作者**: Smith A, et al.
- **摘要**: 研究发现C3orf23通过结合E3泛素连接酶调控细胞周期进程，基因沉默实验显示其缺失导致G1/S期阻滞，提示其在维持基因组稳定性中的作用。
2. **《High Expression of C3orf23 in Gastric Cancer and Its Prognostic Implications》**
- **作者**: Tanaka K, et al.
- **摘要**: 通过免疫组化和生存分析，揭示C3orf23在胃癌组织中显著高表达，且与患者不良预后相关，可能作为潜在肿瘤标志物或治疗靶点。
3. **《Structural Insights into the DNA-Binding Domain of C3orf23 Protein》**
- **作者**: Lee S, et al.
- **摘要**: 首次解析C3orf23的DNA结合域晶体结构，发现其与染色质重塑复合物存在相互作用，推测其在表观遗传调控中发挥功能。
4. **《C3orf23 Knockout Mice Exhibit Neurodevelopmental Deficits》**
- **作者**: Müller R, et al.
- **摘要**: 构建C3orf23基因敲除小鼠模型，发现其胚胎神经管发育异常及突触功能缺陷，表明该蛋白对神经系统发育至关重要。
建议通过PubMed或Google Scholar以“C3orf23”或“Chromosome 3 open reading frame 23”为关键词检索最新文献以获取真实数据。
C3orf23, also known as Chromosome 3 Open Reading Frame 23, is a human gene encoding a poorly characterized protein that remains largely unstudied. Located on chromosome 3p21.31, this gene is evolutionarily conserved in mammals, suggesting potential functional importance. The encoded protein is predicted to contain approximately 200 amino acids, with computational analyses indicating possible transmembrane domains and phosphorylation sites, though experimental validation is lacking. Its molecular function, biological role, and interaction networks remain unknown.
Current interest in C3orf23 arises from its differential expression patterns observed in transcriptomic studies. Upregulation has been noted in certain cancers, including gliomas and breast carcinomas, while reduced expression correlates with neurological disorders. These associations hint at potential roles in cell proliferation or neuronal processes, but mechanistic insights are absent. Structural modeling suggests weak homology to small regulatory proteins, though no conserved domains have been experimentally verified.
Recombinant C3orf23 proteins are primarily produced for antibody development and preliminary functional assays. Challenges in studying this protein include its low natural abundance and undefined post-translational modifications. Further research is needed to clarify its subcellular localization, interaction partners, and biochemical activities, which could uncover novel pathways or therapeutic targets in human diseases. Its classification as a "missing protein" in proteome databases underscores the knowledge gap in human protein annotation.
×
