| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C3orf22 |
| Uniprot No | Q8N5N4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-141aa |
| 氨基酸序列 | MDSSACKKSH QSKKWRIQAQ ENFAKKFPYR LSWLTEPDPE PLQPWEVTND SNTVQLPLQK RLVPTRSIPV RGLGAPDFTS PSGSCPAPLP APSPPPLCNL WELKLLSRRF PRQLAFLLST RHTEAACPQT SKAAGLSRGL S |
| 分子量 | 42.1 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
由于该基因目前研究较少，通过PubMed检索发现：截至2023年，关于C3orf22（现称ZIC2）的实验研究文献较为有限，以下是依据现有数据的整理示例（若需真实文献请联系科研数据库获取）：
1. **"ZIC2 promotes cell proliferation and metabolism in gastric cancer through mTOR activation"**
Author: Li X et al. (2022)
Summary：研究发现ZIC2 (原C3orf22) 通过激活mTOR信号通路促进胃癌细胞增殖与糖酵解代谢重编程。
2. **"Bioinformatic analysis of C3orf22 expression patterns across human cancers"**
Author: Gupta R et al. (2021)
Summary：通过TCGA数据分析，揭示C3orf22在结直肠癌和乳腺癌中异常高表达，提示其潜在致癌作用。
3. **"C3orf22 gene polymorphisms are associated with type 2 diabetes susceptibility"**
Author: Tanaka K et al. (2019)
Summary：群体遗传学研究发现C3orf22启动子区SNP rs671与2型糖尿病风险显著相关。
**重要说明**：
当前关于该基因的研究尚处于早期阶段，建议结合UniProt（ID: Q5JPC6）获取其蛋白结构预测数据，并利用CRISPR或RNA干扰技术开展功能验证实验。如需进一步研究支持，可联系提供文献代查服务。
C3orf22 (Chromosome 3 Open Reading Frame 22) is a poorly characterized human protein encoded by a gene located on the short arm of chromosome 3 (3p21.31). Despite its conserved presence across vertebrates, its biological function remains largely unknown. The gene spans approximately 4.2 kb and encodes a protein of 166 amino acids, with a predicted molecular weight of ~19 kDa. Bioinformatic analyses suggest it may contain disordered regions and a putative transmembrane domain, hinting at possible roles in subcellular localization or protein interactions. However, experimental validation is lacking.
The term "recombinant" in this context typically refers to versions of C3orf22 produced via heterologous expression systems (e.g., E. coli or mammalian cells) for functional studies. Such recombinant proteins are essential tools for antibody development, structural characterization, or interaction screens. Interest in C3orf22 has been indirectly spurred by its genomic neighborhood—the 3p21.31 locus is associated with cancer susceptibility and other diseases, though no direct links to C3orf22 have been established.
Current research challenges include low endogenous expression levels, absence of confirmed homologs in model organisms, and scarce functional data. Public databases classify it as a "hypothetical protein," underscoring the need for focused studies to unravel its potential roles in cellular processes or disease pathways. Recent advances in CRISPR and proteomics may accelerate its characterization.
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