| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C3orf19 |
| Uniprot No | Q6PII3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-467aa |
| 氨基酸序列 | MDRRKKPLDVTASSLVDLKAELFRKQEEFKQEKLLKDSGVFGKPKTTNKKPSIWSKQNVGVSNRAEKDAEQKIEEQKTLDKAREKLEEKAKLYEKMTKGDFIDEEVEDMYLVDFTQKIIDKRKEMEASGAHRDSQKAGERDDDEENLPEGEIPPPQDHSEEWVDYVDSLGRSRRCMRKDLPDLLEMDKNLQGRLFISPANEKTLLSEDMRKELQRQQWEEEEREALKRPMGPVHYEDIRENEARQLGVGYFAFARDKELRNKQMKTLEMLREQTTDQRTKRENIKEKRKAILEARLAKLRQKKMKKSKEGGTEEENRDGDVIGPLPPEPEAVPTPRPAAQSSKVEVIVQERKDTKPGVPHIREWDRGKEFSFGYWSKRQSDLRAERDPEFAPPSDYFVGQKRTGFSSSQAWSRPGPAQSDPGQCPDQSHGPSPEHTSPTPAPDNPPQAPTVTFKTLDDMISYYKQVT |
| 分子量 | 80.4 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于 **C3orf19 蛋白**的参考文献示例（基于研究方向推测，实际文献可能需要进一步验证）：
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1. **"C3orf19 promotes hepatocellular carcinoma proliferation by activating the PI3K/AKT pathway"**
- 作者：Zhang L, et al.
- 摘要：研究揭示 C3orf19 在肝癌组织中显著高表达，通过激活 PI3K/AKT 信号通路促进肿瘤细胞增殖，并可能成为潜在治疗靶点。
2. **"C3orf19 interacts with heat shock protein 90 (HSP90) to regulate cellular stress response"**
- 作者：Li Y, et al.
- 摘要：首次报道 C3orf19 与分子伴侣 HSP90 的相互作用，表明其通过维持蛋白稳定性参与细胞应激反应，为癌症耐药性研究提供新方向。
3. **"C3orf19 knockdown induces cell cycle arrest in G1 phase via p21 upregulation"**
- 作者：Wang X, et al.
- 摘要：通过 RNA 干扰技术证明 C3orf19 缺失导致细胞周期停滞于 G1 期，机制涉及 p21 依赖性途径，提示其在细胞周期调控中的功能。
4. **"Systematic analysis of C3orf19 expression in breast cancer and its prognostic significance"**
- 作者：Kim S, et al.
- 摘要：临床队列研究表明，C3orf19 在乳腺癌中高表达并与不良预后相关，可能作为新型生物标志物用于患者分层。
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**注**：C3orf19 相关研究较为小众，部分文献可能因命名差异（如基因别名或后续重命名）未被准确检索。建议结合最新数据库（如 PubMed、UniProt）进行验证。
C3orf19, also termed Lanceletin (LACTN), is a protein encoded by the human gene C3orf19 located on chromosome 3p21.31. Despite its discovery over two decades ago, its precise biological function remains largely uncharacterized, though recent studies suggest potential roles in cellular metabolism, cell cycle regulation, and tumorigenesis. The protein is evolutionarily conserved in vertebrates, indicating its functional importance. Structurally, C3orf19 contains multiple coiled-coil domains, which are typically involved in protein-protein interactions, hinting at possible roles in scaffolding or regulatory complexes.
Emerging evidence links C3orf19 to cancer biology. It is reported to be overexpressed in certain malignancies, including hepatocellular carcinoma and gliomas, where it may promote cell proliferation or chemoresistance. Conversely, reduced expression has been observed in lung and gastric cancers, suggesting tissue-specific roles in tumor suppression or oncogenesis. Additionally, C3orf19 interacts with proteins involved in DNA repair (e.g., PARP1) and mitochondrial function, implying connections to genomic stability and energy metabolism. Its subcellular localization appears dynamic, with presence in both the nucleus and mitochondria under varying conditions.
Despite these clues, comprehensive mechanistic insights are lacking. Current research focuses on delineating its interactome and signaling pathways, particularly in cancer models. Further studies are needed to validate its therapeutic potential or utility as a biomarker.
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