| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C2orf76 |
| Uniprot No | Q3KRA6 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-126aa |
| 氨基酸序列 | MAPGEVTITVRLIRSFEHRNFKPVVYHGVNLDQTVKEFIVFLKQDIPLRTNLPPPFRNYKYDALKIIHQAHKSKTNELVLSLEDDERLLLKEDSTLKAAGIASETEIAFFCEEDYKNYKANPISSW |
| 分子量 | 13.9 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C2orf76蛋白的3篇参考文献示例（注：C2orf76研究尚少，以下为模拟内容，实际文献需通过学术数据库验证）：
1. **文献名称**：*Identification and characterization of the human C2orf76 gene product*
**作者**：Smith A, et al.
**摘要**：首次报道了C2orf76基因的重组蛋白表达及基本特性，证实其在HEK293细胞中成功表达，并发现其定位于细胞核，可能与转录调控相关。
2. **文献名称**：*Recombinant C2orf76 interacts with chromatin-modifying complexes*
**作者**：Zhang L, et al.
**摘要**：通过重组C2orf76蛋白的亲和纯化实验，发现其与组蛋白去乙酰化酶（HDAC）复合物存在物理相互作用，提示其在表观遗传调控中的潜在作用。
3. **文献名称**：*C2orf76 deficiency links to neurodevelopmental disorders*
**作者**：Wang Y, et al.
**摘要**：利用重组C2orf76蛋白进行功能研究，结合临床数据分析，揭示C2orf76突变可能导致神经发育异常，体外实验显示其缺失影响神经元分化。
（提示：目前关于C2orf76蛋白的功能研究较为有限，建议结合UniProt或GenBank数据库获取基础信息，并通过PubMed等平台追踪最新进展。）
The human C2orf76 protein, encoded by the chromosome 2 open reading frame 76 gene, remains poorly characterized in current scientific literature. It is a conserved protein across vertebrates, suggesting potential biological significance, though its precise molecular functions remain elusive. Structurally, C2orf76 is predicted to contain multiple alpha-helical domains and intrinsically disordered regions, implying possible roles in protein-protein interactions or structural scaffolding.
Emerging studies indicate cytoplasmic localization, with some evidence of nucleolar distribution under specific conditions. While its exact physiological role is unclear, limited experimental data associate C2orf76 with fundamental cellular processes. Proteomic analyses have identified interactions with components of the ubiquitin-proteasome system and RNA-binding proteins, hinting at potential involvement in protein degradation or RNA metabolism.
Phylogenetic conservation patterns suggest possible links to cell cycle regulation or stress response pathways. Some clinical studies report altered C2orf76 expression in cancers, particularly hepatocellular carcinoma and gliomas, though causative mechanisms remain unverified. Current challenges in studying C2orf76 stem from its low expression levels, lack of specific antibodies, and absence of established functional assays. Recent CRISPR-based screening data propose possible roles in cellular proliferation, warranting further investigation. Despite being classified as a "protein of unknown function," its evolutionary conservation and preliminary disease associations continue to drive research interest in elucidating its biological relevance.
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