Recombinant Human C2orf73 Protein

The human C2orf73 protein, encoded by the chromosome 2 open reading frame 73 gene, remains poorly characterized, reflecting its status as an understudied protein with limited functional annotation. Predominantly expressed in tissues like the testes, brain, and kidneys, it is evolutionarily conserved across vertebrates, suggesting potential biological significance. Structural predictions indicate a molecular weight of ~25 kDa and possible coiled-coil domains, which often mediate protein-protein interactions. Current databases classify it as a "protein of unknown function," though emerging studies hint at roles in cellular processes such as cell cycle regulation or DNA repair. A 2021 study linked C2orf73 to interactions with components of the mitotic apparatus, implying involvement in chromosome segregation. Additionally, altered C2orf73 expression has been observed in certain cancers, including gliomas and prostate cancer, where low expression correlates with poor prognosis. Limited *in vitro* data suggest its knockdown disrupts cell proliferation and enhances apoptosis, though mechanistic insights remain elusive. Its subcellular localization, possibly nuclear or cytoplasmic, remains debated. C2orf73’s gene locus overlaps with regions associated with neurodevelopmental disorders, but causal links are unconfirmed. Further investigation is required to clarify its molecular interactions, physiological functions, and therapeutic potential. Recent efforts in structural genomics aim to resolve its 3D conformation, which may accelerate functional discovery. Despite its obscurity, C2orf73 represents a compelling target for unraveling novel pathways in cell biology and disease.