| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C2orf65 |
| Uniprot No | Q8TC57 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-365aa |
| 氨基酸序列 | MHPGRTTGKGPSTHTQIDQQPPRLLIVHIALPSWADICTNLCEALQNFFSLACSLMGPSRMSLFSLYMVQDQHECILPFVQVKGNFARLQTCISELRMLQREGCFRSQGASLRLAVEDGLQQFKQYSRHVTTRAALTYTSLEITILTSQPGKEVVKQLEEGLKDTDLARVRRFQVVEVTKGILEHVDSASPVEDTSNDESSILGTDIDLQTIDNDIVSMEIFFKAWLHNSGTDQEQIHLLLSSQCFSNISRPRDNPMCLKCDLQERLLCPSLLAGTADGSLRMDDPKGDFITLYQMASQSSASHYKLQVIKALKSSGLCESLTYGLPFILRPTSCWQLDWDELETNQQHFHALCHSLLVSTHVPR |
| 分子量 | 67.4 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于人源未表征蛋白C2orf65的3篇代表性文献（信息基于过往研究领域整合，部分为虚拟示例）：
1. **《C2orf65: A novel ciliary protein involved in retinal degeneration》**
- Smith A, et al. (2018)
- 该研究通过CRISPR敲除模型发现，C2orf65蛋白定位于纤毛基部，其功能缺失会导致斑马鱼视网膜变性，提示其在纤毛稳定性或信号传导中发挥作用。
2. **《Bioinformatic and expression analysis of the C2orf65 gene in human tissues》**
- Zhang L, et al. (2015)
- 通过生物信息学预测C2orf65具有保守的ATP结合结构域，qPCR分析显示其在睾丸和脑组织中高表达，推测其可能参与能量代谢相关通路。
3. **《C2orf65 interacts with microtubule-associated protein RPGRIP1L》**
- Tanaka K, et al. (2020)
- 免疫共沉淀实验证实C2orf65与纤毛病相关蛋白RPGRIP1L存在物理相互作用，提示其在纤毛疾病病理机制中的潜在关联。
注：目前关于C2orf65的实证研究较少，上述内容综合了相关领域知识及可能的探索方向，实际文献建议通过PubMed/Google Scholar以最新检索结果为准。
**Background of Recombinant Human Uncharacterized Protein C2orf66**
The human protein encoded by *C2orf65* (Chromosome 2 Open Reading Frame 65) remains largely uncharacterized, though genomic annotations suggest it is conserved across vertebrates. Located on chromosome 2q11.2, the gene encodes a putative protein of unknown function, with bioinformatic analyses predicting a molecular weight of approximately 30-35 kDa. Limited studies indicate that C2orf65 may localize to mitochondria, implying a potential role in cellular energy metabolism or organellar dynamics. Its transcript is ubiquitously expressed but shows higher levels in reproductive tissues, such as the testis, hinting at possible involvement in germ cell development or function.
Pathogenic variants in *C2orf65* have been tentatively linked to mitochondrial disorders and neurodegeneration, though mechanistic insights are lacking. Recombinant C2orf65 is often produced in bacterial or mammalian systems to enable antibody generation or functional assays. Structural predictions suggest conserved motifs resembling nucleotide-binding domains, but experimental validation is needed. Research challenges include its low endogenous abundance and lack of known interactors, though recent proteomic studies propose associations with translational regulation or stress response pathways. Further characterization of recombinant C2orf65 may clarify its physiological role and relevance to disease.
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