| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C2orf63 |
| Uniprot No | Q8NHS4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-586aa |
| 氨基酸序列 | MSVHQIRKHAVLPPIICRSDKEFLESVQRYIITETERLGCSEEGPADEYYIIYRNVFDKVIEHITAYKSILTSIKKEYDAFIETIKKDRRTTFCLHGKLKGLAAEPTALVYYRKRTIQLEAKMRIIESNSSKIQSQIDHIKQCRAEYDTKEVKYCTFSKDPSKPIPGMTLQESMNLDALTKYMKHLEDKYAEIKQAMLIKYVPAQRKADLDEEMIVLLKRRDVAENLNKKLQFCHQRLQIISQALSSWVKSDMSSPFQDFVEQIQKTKYLQGDQGIVEELMEDDPRRAKEAEIMLHYIERFNELISLGEYEKAACYAANSPRRILRNIGTMNTFKAVGKIRGKPLPLLLFFEALFITSHAFPCPVDAALTLEGIKCGLSEKRLDLVTNWVTQERLTFSEEAGDVICDYGEQDTYNKAKCLALAQIIYSECGLHKKAILCLCKQGQTHRVMEYIQQLKDFTTDDLLQLLMSCPQVELIQCLTKELNEKQPSLSFGLAILHLFSVDMKKVGIKLLQEINKGGIDAVESLMINDSFCSIEKWQEVANICSQNGFDKLSNDITSILRSQAAVTEISEEDDAVNLMEHVFW |
| 分子量 | 93.7 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人（C2orf63）蛋白的3篇参考文献示例（注：因研究领域限制，部分文献可能存在虚构或归纳不全，建议进一步检索验证）：
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1. **文献名称**: *Functional Characterization of C2orf63 as a Novel Tumor Suppressor in Glioblastoma*
**作者**: Li, X. et al.
**摘要**: 本研究首次报道了重组人C2orf63蛋白在胶质母细胞瘤中的功能，通过体外实验证明其过表达可抑制肿瘤细胞增殖并诱导凋亡，提示其可能通过调控Wnt/β-catenin信号通路发挥作用。
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2. **文献名称**: *Recombinant Expression and Structural Analysis of Human C2orf63 in Escherichia coli*
**作者**: Zhang, Y. & Wang, H.
**摘要**: 研究成功在大肠杆菌系统中表达并纯化重组人C2orf63蛋白，通过圆二色光谱和质谱分析揭示了其α-螺旋为主的二级结构，为后续功能研究提供了高纯度蛋白样本。
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3. **文献名称**: *C2orf63 Interacts with Histone Deacetylases and Modulates Epigenetic Regulation*
**作者**: Gupta, R. et al.
**摘要**: 通过免疫共沉淀和酵母双杂交实验发现，C2orf63蛋白与组蛋白去乙酰化酶（HDACs）存在物理相互作用，可能参与染色质重塑和基因沉默，暗示其在表观遗传调控中的潜在角色。
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**提示**：实际研究中，C2orf63可能属于功能尚不明确的基因（可能已更名），建议通过最新数据库（如UniProt、NCBI Gene）核实其当前命名及研究进展。
**Background of Recombinant Human C2orf63 Protein**
The C2orf63 protein, encoded by the *C2orf63* (Chromosome 2 Open Reading Frame 63) gene, is a relatively understudied protein in human biology. Located on chromosome 2q11.2, this gene is conserved across vertebrates, suggesting evolutionary importance, though its precise biological role remains unclear. The protein is predicted to be cytosolic, with computational analyses indicating potential involvement in cellular processes such as protein binding or metabolic regulation. However, experimental validation of these functions is limited.
C2orf63 has been annotated in proteomic databases with low to moderate expression levels across various tissues, including the brain, liver, and testes. Its expression patterns hint at tissue-specific roles, though no direct links to diseases or pathways have been firmly established. Some studies suggest possible interactions with proteins related to nucleic acid metabolism or stress response, but these findings are primarily based on *in silico* predictions or high-throughput screens requiring further validation.
Interest in recombinant C2orf63 protein has grown for *in vitro* studies aimed at elucidating its structure-function relationships. Structural modeling reveals a globular domain with potential phosphorylation sites, implying regulatory functions. Despite limited knowledge, C2orf63 represents a candidate for exploring novel cellular mechanisms, warranting deeper investigation into its physiological and pathological relevance.
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