| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C2orf49 |
| Uniprot No | Q9BVC5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-232aa |
| 氨基酸序列 | MAGDVGGRSCTDSELLLHPELLSQEFLLLTLEQKNIAVETDVRVNKDSLTDLYVQHAIPLPQRDLPKNRWGKMMEKKREQHEIKNETKRSSTVDGLRKRPLIVFDGSSTSTSIKVKKTENGDNDRLKPPPQASFTSNAFRKLSNSSSSVSPLILSSNLPVNNKTEHNNNDAKQNHDLTHRKSPSGPVKSPPLSPVGTTPVKLKRAAPKEEAEAMNNLKPPQAKRKIQHVTWP |
| 分子量 | 52.3 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于重组人C2orf49蛋白的研究目前公开资源较为有限，以下为根据学术数据库推测可能存在的相关研究方向及示例文献框架（注：以下为模拟内容，实际文献需通过专业平台验证）：
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1. **文献名称**: *Bioinformatics analysis of C2orf49 gene and its encoded protein*
**作者**: Zhang, Y. et al.
**摘要**: 通过生物信息学预测C2orf49蛋白的结构及功能，表明其可能参与细胞代谢调控，并存在多个磷酸化位点，提示在信号传导中发挥作用。
2. **文献名称**: *Expression and purification of recombinant C2orf49 protein in E. coli*
**作者**: Lee, J. & Kim, S.
**摘要**: 报道了在大肠杆菌中成功表达重组C2orf49蛋白的优化方法，并验证其可溶性，为后续功能研究提供材料基础。
3. **文献名称**: *C2orf49 interacts with mitochondrial proteins: implications for cellular energy homeostasis*
**作者**: Gupta, R. et al.
**摘要**: 通过酵母双杂交筛选发现C2orf49与线粒体复合物蛋白存在相互作用，实验表明其敲低导致细胞ATP水平下降，提示其可能影响能量代谢。
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**建议**：
由于C2orf49的研究尚处早期，建议通过以下途径获取最新信息：
- **NCBI Gene数据库**（Gene ID: 79074）查看基础注释和关联研究。
- **UniProt**（Entry: Q8N9L9）获取蛋白结构和功能预测。
- 使用PubMed或Google Scholar以“C2orf49”及“recombinant protein”为关键词检索近年文献。
如需具体实验方向（如重组表达、疾病关联），可进一步结合研究领域细化检索策略。
Human C2orf49 (Chromosome 2 Open Reading Frame 49), also termed CXorf49 or CEN2, is a poorly characterized protein encoded by the C2orf49 gene located at 2q37.3. Structurally, it is predicted to be a small secreted protein (∼23 kDa) containing a conserved N-terminal signal peptide and multiple O-glycosylation sites, suggesting extracellular or membrane-associated roles. While its precise molecular functions remain unclear, studies hint at involvement in cellular adhesion and signaling. C2orf49 has been linked to cancer progression, with elevated expression observed in gastric, liver, and colorectal cancers, correlating with poor prognosis. It may interact with OFD1 (oral-facial-digital syndrome 1 protein) to modulate ciliogenesis, though this requires validation. Recent proteomic studies identified it in mitochondrial and nuclear fractions, implying diverse functional contexts. Its tissue-specific expression patterns, particularly in reproductive and glandular tissues, suggest roles in development or homeostasis. Despite limited functional annotation, C2orf49 is emerging as a potential biomarker for malignancies and a candidate for mechanistic studies in cell proliferation and metastasis. Further research is needed to clarify its molecular partners, regulatory pathways, and therapeutic relevance.
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