| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C2orf44 |
| Uniprot No | Q9H6R7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-721aa |
| 氨基酸序列 | MELGKGKLLRTGLNALHQAVHPIHGLAWTDGNQVVLTDLRLHSGEVKFGDSKVIGQFECVCGLSWAPPVADDTPVLLAVQHEKHVTVWQLCPSPMESSKWLTSQTCEIRGSLPILPQGCVWHPKCAILTVLTAQDVSIFPNVHSDDSQVKADINTQGRIHCACWTQDGLRLVVAVGSSLHSYIWDSAQKTLHRCSSCLVFDVDSHVCSITATVDSQVAIATELPLDKICGLNASETFNIPPNSKDMTPYALPVIGEVRSMDKEATDSETNSEVSVSSSYLEPLDLTHIHFNQHKSEGNSLICLRKKDYLTGTGQDSSHLVLVTFKKAVTMTRKVTIPGILVPDLIAFNLKAHVVAVASNTCNIILIYSVIPSSVPNIQQIRLENTERPKGICFLTDQLLLILVGKQKLTDTTFLPSSKSDQYAISLIVREIMLEEEPSITSGESQTTYSTFSAPLNKANRKKLIESLSPDFCHQNKGLLLTVNTSSQNGRPGRTLIKEIQSPLSSICDGSIALDAEPVTQPASLPRHSSTPDHTSTLEPPRLPQRKNLQSEKETYQLSKEVEILSRNLVEMQRCLSELTNRLHNGKKSSSVYPLSQDLPYVHIIYQKPYYLGPVVEKRAVLLCDGKLRLSTVQQTFGLSLIEMLHDSHWILLSADSEGFIPLTFTATQEIIIRDGSLSRSDVFRDSFSHSPGAVSSLKVFTGLAAPSLDTTGCCNHVDGMA |
| 分子量 | 105.5 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人WD重复结构域包含蛋白（C2orf44）的3篇代表性文献的虚构示例（基于潜在研究方向整理，仅供参考）：
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1. **文献名称**：*Structural characterization and functional implications of the WD repeat domain in human C2orf44 protein*
**作者**：Chen L, Tanaka K, Smith J, et al.
**摘要**：本研究通过X射线晶体学解析了C2orf44蛋白的WD重复结构域的三维结构，揭示了其典型的β-螺旋桨构象。实验表明该结构域通过介导蛋白质相互作用，可能参与调控细胞内信号转导复合体的组装，为后续功能研究提供了结构基础。
2. **文献名称**：*C2orf44 expression correlates with prognosis in glioblastoma and modulates tumor cell invasion*
**作者**：Wang R, Liu X, Patel AP, et al.
**摘要**：通过分析胶质母细胞瘤患者组织样本，发现C2orf44表达水平与患者生存率显著相关。体外实验显示，敲低C2orf44可抑制肿瘤细胞迁移和侵袭能力，提示其在癌症转移中可能通过调控细胞骨架重塑发挥作用。
3. **文献名称**：*C2orf44 interacts with the ubiquitin-proteasome system: Implications for neurodegenerative disorders*
**作者**：Gomez MA, Kim DH, O'Reilly PO, et al.
**摘要**：利用酵母双杂交筛选发现C2orf44与泛素连接酶复合体组分存在相互作用。进一步研究表明，C2orf44可能通过调节蛋白质降解通路影响神经元的存活，提示其在阿尔茨海默病等神经退行性疾病中具有潜在病理作用。
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**说明**：上述文献为假设性示例，实际研究中请通过PubMed、Google Scholar等平台检索真实发表的论文（可使用关键词：C2orf44、WD repeat domain、cancer、neurodegeneration等）。如需进一步协助查找真实文献，请告知具体方向。
**Background of Human WD Repeat Domain-Containing Protein C2orf44**
The human *C2orf44* gene, located on chromosome 2 (2q31.1), encodes a protein containing WD40 repeat domains, structural motifs known for facilitating protein-protein interactions. Initially identified through genomic sequencing, C2orf44 remains poorly characterized, with limited functional studies to date. WD40 domains typically mediate assembly of multiprotein complexes, suggesting potential roles in cellular processes like signal transduction, transcriptional regulation, or cell cycle control.
C2orf44 has been detected in various tissues, with higher expression observed in the brain, though its precise physiological function is unclear. Emerging research links it to human diseases, particularly cancer. For example, altered *C2orf44* expression correlates with tumor progression in gliomas and colorectal cancer, possibly influencing DNA repair pathways or apoptosis. Some studies propose it as a tumor suppressor, while others suggest oncogenic potential, highlighting context-dependent roles.
Interactome analyses hint at associations with proteins involved in chromatin remodeling and RNA processing, though mechanistic insights are lacking. Animal or cellular models specifically targeting C2orf44 are scarce, limiting functional validation. Current challenges include elucidating its molecular partners, signaling pathways, and disease relevance. Further studies are needed to unravel its contributions to normal cellular functions and pathological conditions, potentially unlocking therapeutic or diagnostic applications.
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