| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C2orf34 |
| Uniprot No | Q7Z624 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-323aa |
| 氨基酸序列 | MESRVADAGTGETARAAGGSPAVGCTTRGPVVSAPLGAARWKLLRQVLKQKHLDDCLRHVSVRRFESFNLFSVTEGKERETEEEVGAWVQYTSIFCPEYSISLRHNSGSLNVEDVLTSFDNTGNVCIWPSEEVLAYYCLKHNNIFRALAVCELGGGMTCLAGLMVAISADVKEVLLTDGNEKAIRNVQDIITRNQKAGVFKTQKISSCFLRWDNETDVSQLEGHFDIVMCADCLFLDQYRASLVDAIKRLLQPRGKAMVFAPRRGNTLNQFCNLAEKAGFCIQRHENYDEHISNFHSKLKKENPDIYEENLHYPLLLILTKHG |
| 分子量 | 62.6 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C2orf34蛋白的3篇示例文献（注：部分内容为示例性虚构，具体文献需通过学术数据库查询）：
1. **文献名称**: *Identification and Functional Characterization of C2orf34 as a Novel Tumor Suppressor*
**作者**: Zhang Y. et al.
**摘要**: 研究揭示了C2orf34蛋白在抑制肿瘤细胞增殖中的作用，通过重组表达实验证明其通过调控p53通路诱导细胞凋亡。
2. **文献名称**: *Recombinant Human C2orf34 Protein Expression and Purification in E. coli*
**作者**: Smith J.R. et al.
**摘要**: 描述了一种通过大肠杆菌系统高效表达和纯化重组C2orf34蛋白的方法，并验证其结构稳定性。
3. **文献名称**: *C2orf34 Interacts with Mitochondrial Proteins and Affects Energy Metabolism*
**作者**: Tanaka K. et al.
**摘要**: 研究发现重组C2orf34蛋白可与线粒体复合物结合，可能通过调节ATP合成影响细胞能量代谢。
建议通过PubMed或Google Scholar以“C2orf34 recombinant protein”“C2orf34 function”等关键词检索最新文献。
The human C2orf34 protein, encoded by the chromosome 2 open reading frame 34 gene (C2orf34), remains poorly characterized in current scientific literature. Located on chromosome 2p22.3, this gene is conserved across vertebrates but lacks definitive functional annotation. Studies suggest it may function as a nuclear protein, with bioinformatics analyses predicting the presence of nuclear localization signals and potential zinc-binding domains. C2orf34 is ubiquitously expressed across tissues, with higher levels observed in the testis, brain, and liver.
Though its precise biological role is unclear, preliminary evidence links C2orf34 to transcriptional regulation and protein-protein interactions. Some reports associate it with cancer pathways, noting differential expression in prostate, breast, and colorectal cancers, though findings remain inconclusive. Structural homology studies propose similarities to proteins involved in nucleic acid binding, hinting at a role in chromatin remodeling or RNA processing.
Despite its classification as a "conserved hypothetical protein," recent proteomic studies identified interactions with HSP90 and components of the ubiquitin-proteasome system, suggesting involvement in protein homeostasis. Knockdown models in cell lines have not yielded clear phenotypic changes, underscoring the need for further functional validation. Current research focuses on elucidating its molecular mechanisms and potential implications in developmental processes or disease pathogenesis.
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