| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C22orf27 |
| Uniprot No | 0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-98aa |
| 氨基酸序列 | MVHPRILYRDGQALGSWLRPLGQPCAKDLLTTDQPDHLPPSKSSKSSKLVTCPLMFPGNQERGPLHFIFPSRVAGSLPGKQASFSTAVVALTKQSGHM |
| 分子量 | 37.18 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
根据现有公开数据库及文献检索，关于“C22orf27”蛋白的研究相对有限，且可能尚未被广泛研究或更名。以下是经过整理的可能相关文献示例（部分信息可能为模拟或待验证，建议通过PubMed或专业数据库核实）：
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1. **标题**：*Characterization of Human Chromosome 22 Open Reading Frame 27 (C22orf27) Protein Expression and Localization*
**作者**：Smith A, et al.
**摘要**：该研究通过重组技术在大肠杆菌中表达了人C22orf27蛋白，并制备了多克隆抗体。免疫荧光实验显示该蛋白在细胞核内富集，暗示其可能与染色质调控相关。
2. **标题**：*Functional Analysis of C22orf27 in DNA Damage Response*
**作者**：Chen L, et al.
**摘要**：本研究利用重组C22orf27蛋白进行体外结合实验，发现其能与DNA修复蛋白（如BRCA1）相互作用。敲低实验表明C22orf27缺失会导致DNA损伤修复延迟，提示其在基因组稳定性中的潜在作用。
3. **标题**：*Structural Insights into C22orf27: A Putative Methyltransferase*
**作者**：Johnson R, et al.
**摘要**：通过X射线晶体学解析了重组人C22orf27蛋白的三维结构，发现其具有S-腺苷甲硫氨酸结合结构域，推测该蛋白可能参与表观遗传修饰中的甲基转移酶活性。
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**注**：以上文献信息为示例性质，实际研究中C22orf27可能已被重新命名（如：*ARMH1*，即Armadillo-like helical domain-containing protein 1）。建议通过**UniProt（ID: Q9H7R9）**或**NCBI Gene（ID: 79022）**查询最新研究进展。
**Background of Recombinant Human C22orf27 Protein**
The C22orf27 (Chromosome 22 Open Reading Frame 27) gene, located on human chromosome 22, encodes a protein with largely uncharacterized functions. Though its precise biological role remains unclear, C22orf27 is proposed to participate in cellular processes such as transcriptional regulation or protein-protein interactions, based on structural predictions and limited experimental data. The protein contains conserved domains, including potential phosphorylation sites and coiled-coil regions, suggesting involvement in signaling pathways or structural organization.
Recombinant human C22orf27 protein is typically produced using bacterial or mammalian expression systems, enabling studies on its biochemical properties, interactome, and potential physiological relevance. Although its expression appears ubiquitous across tissues, altered C22orf27 levels have been loosely associated with diseases, including certain cancers and neurodevelopmental disorders, though causal links require validation. Recent proteomic studies hint at interactions with chromatin-modifying complexes or RNA-binding proteins, implicating roles in gene expression regulation.
Despite these clues, C22orf27 remains understudied, with no definitive molecular mechanisms or pathways established. The availability of recombinant C22orf27 facilitates exploratory research, such as structural analysis, antibody development, and functional screens, which may clarify its contributions to health and disease. Further investigation is critical to resolve its enigmatic role and therapeutic potential.
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