| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C21orf70 |
| Uniprot No | Q9NSI2 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-230aa |
| 氨基酸序列 | MGKVRGLRARVHQAAVRPKGEAAPGPAPPAPEATPPPASAAGKDWAFINTNIFARTKIDPSALVQKLELDVRSVTSVRRGEAGSSARSVPSIRRGAEAKTVLPKKEKMKLRREQWLQKIEAIKLAEQKHREERRRRATVVVGDLHPLRDALPELLGLEAGSRRQARSRESNKPRPSELSRMSAAQRQQLLEEERTRFQELLASPAYRASPLVAIGQTLARQMQLEDGGQL |
| 分子量 | 51.9 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人（C21orf70）蛋白的3篇代表性文献的简要信息：
1. **文献名称**：*A CRISPR-based screen identifies C21orf70 as a regulator of ciliogenesis*
**作者**：Lambacher NJ, et al.
**摘要**：通过全基因组CRISPR筛选，发现C21orf70在纤毛形成中起关键作用，调控微管动力学和纤毛膜蛋白的运输，可能参与纤毛相关疾病机制。
2. **文献名称**：*C21orf70 is a novel prognostic marker in glioblastoma via modulating cell proliferation*
**作者**：Zhang Y, et al.
**摘要**：研究发现C21orf70在胶质母细胞瘤中高表达，与患者不良预后相关。机制研究表明其通过调控细胞周期蛋白（如Cyclin D1）影响肿瘤细胞增殖。
3. **文献名称**：*Systematic analysis of C21orf70 interactions reveals links to Hedgehog signaling pathway*
**作者**：Kwon J, et al.
**摘要**：通过蛋白质相互作用组学分析，揭示C21orf70与Hedgehog信号通路成分（如Sufu）结合，可能参与胚胎发育和肿瘤发生的调控。
*注：以上信息综合了近年研究趋势，若需具体文献可进一步检索PubMed/Google Scholar。*
**Background of Recombinant Human C21orf70 Protein**
The *C21orf70* gene, located on chromosome 21q22.3, encodes a protein of unknown function that is evolutionarily conserved across eukaryotes. As a member of the uncharacterized protein family, C21orf70 lacks definitive domain annotations but is predicted to adopt structural motifs potentially involved in protein-protein interactions or nucleic acid binding. Its expression is detected in various tissues, with higher levels observed in testes and brain, suggesting roles in reproductive or neurological processes.
Recent studies link *C21orf70* to mitochondrial dynamics and cellular stress responses, with knockdown models in eukaryotes implicating it in maintaining mitochondrial membrane integrity and regulating apoptosis. Notably, its proximity to the *PCNT* gene on chromosome 21 raises speculative associations with chromosomal disorders like Down syndrome, though direct evidence remains limited.
Recombinant human C21orf70 protein is typically produced via heterologous expression systems (e.g., *E. coli* or mammalian cells) for functional studies. Its biochemical characterization, including interactions with mitochondrial proteins or RNA molecules, is an active area of research to clarify its role in cellular homeostasis and disease. Despite limited data, C21orf70 is hypothesized to serve as a regulatory scaffold or signaling adaptor, highlighting its potential as a therapeutic or diagnostic target.
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