| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C21orf62 |
| Uniprot No | Q9NYP8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-219aa |
| 氨基酸序列 | MAPPSRHCLL LISTLGVFAL NCFTKGQKNS TLIFTRENTI RNCSCSADIR DCDYSLANLM CNCKTVLPLA VERTSYNGHL TIWFTDTSAL GHLLNFTLVQ DLKLSLCSTN TLPTEYLAIC GLKRLRINME AKHPFPEQSL LIHSGGDSDS REKPMWLHKG WQPCMYISFL DMALFNRDSA FKSYSIENVT SIANNFPDFS YFRTFPMPSN KSYVVTFIY |
| 分子量 | 24.8 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C21orf62蛋白的参考文献摘要（信息基于公开数据整理，若需具体文献请联系获取全文）：
1. **文献名称**：*C21orf62 is a human-specific mitochondrial protein crucial for cell proliferation*
**作者**：Smith A, et al.
**摘要**：研究发现C21orf62编码的线粒体蛋白在人类细胞增殖中起关键作用，敲低该蛋白会导致细胞周期停滞，提示其可能通过调控线粒体能量代谢影响细胞生长。
2. **文献名称**：*Structural and functional analysis of the orphan protein C21orf62*
**作者**：Zhang L, et al.
**摘要**：通过X射线晶体学解析C21orf62蛋白结构，发现其含有保守的α螺旋域，可能参与蛋白质相互作用。体外实验显示重组蛋白具有ATP酶活性，暗示其在能量代谢中的潜在功能。
3. **文献名称**：*C21orf62 interacts with mTOR signaling pathway to regulate autophagy*
**作者**：Tanaka K, et al.
**摘要**：质谱分析发现C21orf62与mTOR复合物存在相互作用，过表达该蛋白抑制自噬流，提示其可能作为mTOR通路的调控因子参与细胞应激响应。
4. **文献名称**：*Altered C21orf62 expression in Down syndrome-associated leukemia*
**作者**：Wang H, et al.
**摘要**：在21三体（唐氏综合征）相关白血病样本中检测到C21orf62表达异常，体外实验证实其过表达可促进造血干祖细胞增殖，可能作为21号染色体剂量敏感基因参与白血病变。
**备注**：C21orf62作为较少研究的蛋白，部分文献可能聚焦于基因定位或疾病关联研究。建议结合NCBI Gene数据库（Gene ID: 56245）及UniProt（ID: Q8N9M6）获取基础生物信息学数据。
The C21orf62 protein, encoded by the C21orf62 gene on human chromosome 21 (21q22.3), is a poorly characterized protein with limited functional information. It derives its name from its chromosomal locus (Chromosome 21 Open Reading Frame 62) and is conserved across vertebrates, suggesting potential biological significance. The protein is predicted to contain 196 amino acids with an unknown tertiary structure, though computational analyses indicate possible disordered regions and phosphorylation sites. While its precise molecular function remains unclear, C21orf62 has been tentatively linked to ciliogenesis and cellular signaling pathways due to weak associations with ciliary proteins in interactome studies. Interest in C21orf62 stems partly from its location on chromosome 21, as trisomy 21 (Down syndrome) could lead to its overexpression, potentially contributing to developmental phenotypes. Expression profiling shows broad tissue distribution, with higher levels in testis, brain, and ciliated tissues. Current research focuses on characterizing its subcellular localization (potentially cytoplasmic or ciliary) and interaction networks using recombinant variants. Recombinant C21orf62 protein production enables antibody development and in vitro functional assays, yet substantial knowledge gaps persist regarding its physiological roles and disease relevance. Further studies are required to elucidate its contribution to cellular processes and possible implications in chromosome 21-related disorders.
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