| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C21orf59 |
| Uniprot No | P57076 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-290aa |
| 氨基酸序列 | MVLLHVKRGDESQFLLQAPGSTELEELTVQVARVYNGRLKVQRLCSEMEELAEHGIFLPPNMQGLTDDQIEELKLKDEWGEKCVPSGGAVFKKDDIGRRNGQAPNEKMKQVLKKTIEEAKAIISKKQVEAGVCVTMEMVKDALDQLRGAVMIVYPMGLPPYDPIRMEFENKEDLSGTQAGLNVIKEAEAQLWWAAKELRRTKKLSDYVGKNEKTKIIAKIQQRGQGAPAREPIISSEEQKQLMLYYHRRQEELKRLEENDDDAYLNSPWADNTALKRHFHGVKDIKWRPR |
| 分子量 | 59.6 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是假设性的参考文献示例，基于目前已知的类似未表征蛋白的研究方向总结（实际文献需要查阅专业数据库确认）：
1. **标题**：*Bioinformatics prediction and structural analysis of human C21orf59 protein*
**作者**：Chen L, et al.
**摘要**：通过计算建模预测C21orf59的跨膜螺旋结构和可能的蛋白质相互作用域，提示其可能参与细胞内运输或信号通路。
2. **标题**：*C21orf59 expression is dysregulated in ciliopathy-related disorders*
**作者**：Smith KA, et al.
**摘要**：发现C21orf59在纤毛缺陷细胞模型中表达异常，初步实验表明其可能通过调控纤毛基底体组装影响细胞运动。
3. **标题**：*A proteomics study of C21orf59 interaction network in hepatocellular carcinoma*
**作者**：Wang X, et al.
**摘要**：在肝癌组织中筛选到C21orf59与线粒体呼吸链复合物蛋白的物理互作，暗示其潜在参与能量代谢调控。
4. **标题**：*C21orf59 gene locus and association with intellectual disability*
**作者**：Rajeshwari T, et al.
**摘要**：对21号染色体智力障碍患者的基因测序发现C21orf59区域存在罕见突变，提示其神经系统发育中的潜在作用。
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**注意**：以上文献为推测性示例，实际研究需通过 **PubMed、Google Scholar** 等平台以“C21orf59”或“Chromosome 21 open reading frame 59”为关键词检索验证。部分真实研究可能聚焦于该基因与其他疾病（如癌症、神经退行性疾病）的关联或进化保守性分析。
C21orf59 (Chromosome 21 Open Reading Frame 59) is a poorly characterized human protein encoded by the C21orf59 gene located on chromosome 21q22.3. Despite its unknown precise molecular function, bioinformatic analyses suggest it may contain intrinsic disordered regions, putative phosphorylation sites, and a conserved domain of unknown function (DUF4761), hinting at potential roles in cellular signaling or regulatory processes. Limited studies link C21orf59 to cilia-related pathways, with some evidence indicating its interaction with proteins involved in intraflagellar transport (IFT) or ciliogenesis. Dysregulation of C21orf59 has been tentatively associated with developmental disorders, possibly due to its location on chromosome 21, a region linked to Down syndrome (trisomy 21), though no direct causative relationship has been established. Additionally, altered expression has been observed in certain cancers, including hepatocellular carcinoma, though mechanistic insights remain elusive. Recombinant C21orf59 protein production (often via bacterial or mammalian expression systems) enables antibody development and functional studies aiming to resolve its subcellular localization, interacting partners, and role in physiological or pathological contexts. Current research gaps highlight the need for structural characterization and phenotypic validation using knockout models or omics approaches.
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