| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C21orf33 |
| Uniprot No | P30042 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-268aa |
| 氨基酸序列 | MAAVRALVASRLAAASAFTSLSPGGRTPSQRAALHLSVPRPAARVALVLSGCGVYDGTEIHEASAILVHLSRGGAEVQIFAPDVPQMHVIDHTKGQPSEGESRNVLTESARIARGKITDLANLSAANHDAAIFPGGFGAAKNLSTFAVDGKDCKVNKEVERVLKEFHQAGKPIGLCCIAPVLAAKVLRGVEVTVGHEQEEGGKWPYAGTAEAIKALGAKHCVKEVVEAHVDQKNKVVTTPAFMCETALHYIHDGIGAMVRKVLELTGK |
| 分子量 | 54.5 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C21orf33蛋白的虚构参考文献示例，仅供格式参考（实际文献需通过学术数据库查询）：
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1. **文献名称**：*Characterization of Recombinant Human C21orf33 as a Mitochondrial Stress Response Protein*
**作者**：Smith A, et al.
**摘要**：本研究成功在大肠杆菌中表达并纯化了重组人C21orf33蛋白，发现其定位于线粒体，并在氧化应激条件下调节细胞凋亡，提示其可能参与线粒体功能障碍相关疾病。
2. **文献名称**：*Structural Analysis of C21orf33 Reveals RNA-Binding Motifs*
**作者**：Jones B, et al.
**摘要**：通过X射线晶体学解析重组C21orf33的三维结构，发现其N端含有保守的RNA结合结构域，实验证实其与特定mRNAs的相互作用，可能参与转录后调控。
3. **文献名称**：*C21orf33 Knockdown and Recombinant Rescue in Neurodegenerative Models*
**作者**：Zhang C, et al.
**摘要**：在神经细胞模型中，敲低C21orf33导致突触蛋白异常聚集，而添加重组C21orf33可逆转表型，表明其在神经退行性疾病中的潜在保护作用。
4. **文献名称**：*C21orf33 Modulates Inflammatory Signaling via NF-κB Pathway*
**作者**：Lee D, et al.
**摘要**：发现重组C21orf33通过直接结合IKK复合物抑制NF-κB活化，在炎症反应中起负调控作用，为治疗炎症性疾病提供新靶点。
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**注意**：以上文献为示例性质，非真实存在。建议通过PubMed、Google Scholar等平台，使用关键词“C21orf33 recombinant protein”“C21orf33 function”检索真实文献。若需特定研究方向（如疾病关联、结构等），可进一步筛选。
The human C21orf33 protein, also known as PCARE or C21orf33, is encoded by the C21orf33 gene located on chromosome 21q22.11. This evolutionarily conserved protein is ubiquitously expressed, with notable abundance in the brain, retina, and testis. Structurally, it contains a conserved SUMO interaction motif (SIM) and putative zinc finger domains, suggesting roles in protein interactions and nucleic acid binding. Though its precise molecular functions remain incompletely characterized, emerging studies implicate C21orf33 in cellular stress response pathways, mitochondrial homeostasis, and RNA metabolism.
Research highlights its potential involvement in neurodegenerative diseases and cancer progression. Intriguingly, its chromosomal location associates it with Down syndrome (trisomy 21), though direct pathological links require further validation. Recombinant C21orf33 proteins (typically 20-25 kDa) have been engineered for functional studies, enabling investigations into its subcellular localization (predominantly cytoplasmic/nuclear) and post-translational modifications. Recent interactome analyses suggest partnerships with DNA repair proteins and RNA-binding factors, hinting at roles in genome stability or transcriptional regulation.
While still classified as a protein of unknown function (UniProt: Q8NHS8), C21orf33's conservation across vertebrates and disease-associated genomic context drive growing interest in its biological significance and therapeutic potential.
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