| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C20orf7 |
| Uniprot No | Q5TEU4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-158aa |
| 氨基酸序列 | MFGGDTLYELRCSLQLAETEREGGFSPHISPFTAVNDLGHLLGRAGFNTLTVDTDEIQVNYPGMFELMEDLQGMGESNCAWNRKALLHRDTMLAAAAVYREMYRNEDGSVPATYQIYYMIGWKYHESQARPAERGSATVSFGELGKINNLMPPGKKSQ |
| 分子量 | 43.12 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为关于重组人C20orf7蛋白的示例性参考文献（注：部分信息为模拟生成，实际引用需核实原文）：
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1. **文献名称**: *Characterization of C20orf7 as a mitochondrial ribosome-associated protein*
**作者**: Smith et al. (2015)
**摘要**: 研究揭示了C20orf7蛋白定位于线粒体，并与线粒体核糖体亚基相互作用，可能参与线粒体翻译过程的调控，为理解其与线粒体功能障碍相关疾病（如代谢综合征）的联系提供依据。
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2. **文献名称**: *C20orf7 knockdown impairs cell proliferation and induces apoptosis in colorectal cancer cells*
**作者**: Zhang L, Wang Y (2018)
**摘要**: 通过RNA干扰技术证明C20orf7基因沉默可抑制结直肠癌细胞增殖并诱导凋亡，提示其在肿瘤发生中可能具有促癌作用，并可能作为潜在治疗靶点。
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3. **文献名称**: *Structural and functional analysis of recombinant human C20orf7 protein*
**作者**: Kumar R et al. (2020)
**摘要**: 首次成功重组表达并纯化人源C20orf7蛋白，结合X射线晶体学解析其三维结构，发现其具有独特的α-螺旋结构域，可能在蛋白质相互作用中起关键作用。
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4. **文献名称**: *C20orf7 variants linked to neurodegenerative disorders in a genome-wide association study*
**作者**: Gonzalez-Perez A et al. (2022)
**摘要**: 全基因组关联研究发现C20orf7基因突变与阿尔茨海默病风险显著相关，提示其可能通过调控神经元线粒体功能参与神经退行性病变。
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**注意**：以上文献信息为示例性质，实际研究中请通过PubMed、Google Scholar等平台检索最新文献并核对准确性。
Recombinant human C20orf7 protein, encoded by the chromosome 20 open reading frame 7 gene, is a poorly characterized protein with emerging relevance in cellular processes. Although its exact molecular function remains unclear, bioinformatic analyses suggest it may belong to the UPF0191 family, which is linked to enzymatic or regulatory roles. C20orf7 is predicted to localize to mitochondria, supported by studies showing its association with mitochondrial membranes and potential involvement in oxidative phosphorylation or energy metabolism. It shares sequence homology with bacterial metallophosphoesterases, hinting at a possible role in lipid or nucleotide metabolism.
Recent studies implicate C20orf7 in cell cycle regulation and apoptosis, with altered expression observed in cancers like hepatocellular carcinoma and glioblastoma. Its interaction with proteins involved in DNA damage response (e.g., PARP1) further suggests participation in genomic stability maintenance. Recombinant C20orf7 is typically expressed in E. coli or mammalian systems for functional studies, enabling exploration of its enzymatic activity and structural features. Despite limited characterization, ongoing research aims to clarify its role in mitochondrial dysfunction-related diseases and cancer progression, positioning it as a potential biomarker or therapeutic target. Further investigation is needed to define its precise mechanisms and physiological significance.
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