| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C20orf71 |
| Uniprot No | Q9BQP9 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-218aa |
| 氨基酸序列 | MMCPLWRLLIFLGLLALPLAPHKQPWPGLAQAHRDNKSTLARIIAQGLIKHNAESRIQNIHFGDRLNASAQVAPGLVGWLISGRKHQQQQESRSFDNNIVKMCAHMSIVVEFWLEKDEFGRRDLVIGKCDAEPSSVHVAILTEAIPPKMNQFLYNLKENLQKVLPHMVESQVCPLIGEILGQLDVKLLKSLIEQEAAHEPTHHETSQPSACQAGESPS |
| 分子量 | 50.8 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C20orf71蛋白的三篇文献摘要及作者信息（注：C20orf71研究可能有限，以下为模拟示例）：
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1. **文献名称**: *C20orf71 encodes a novel phosphorylation-dependent protein regulating ciliogenesis in human cells*
**作者**: Zhang et al. (2018)
**摘要**: 研究发现重组人C20orf71蛋白在纤毛形成中起关键作用，通过磷酸化修饰与纤毛基体蛋白相互作用，敲低C20orf71导致纤毛结构异常，提示其在发育缺陷相关疾病中的潜在作用。
2. **文献名称**: *Structural and functional characterization of the C20orf71 protein family*
**作者**: Müller et al. (2020)
**摘要**: 通过重组表达纯化人C20orf71蛋白，解析其晶体结构，揭示其具有典型的α/β水解酶折叠，并发现其可能在脂质代谢中具有酶活性，但具体底物尚待验证。
3. **文献名称**: *SPATA20 (C20orf71) mutations associated with male infertility disrupt testis-specific protein interactions*
**作者**: Li et al. (2019)
**摘要**: 发现C20orf71（SPATA20）在睾丸中高表达，重组蛋白实验显示其与精子发生相关蛋白（如TSSK6）结合，基因突变导致男性不育，强调其生殖系统功能的重要性。
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**备注**：因部分基因功能研究尚不完善，实际文献可能需要通过PubMed或UniProt数据库进一步核实。建议结合 **C20orf71（现名SPATA20）** 的别名查询更新研究。
The recombinant human C20orf71 protein, now commonly referred to as SPATA20 (spermatogenesis-associated protein 20), is encoded by the C20orf71 gene located on chromosome 20 (20q11.22). Predominantly expressed in the testis, SPATA20 is implicated in spermatogenesis, particularly in sperm maturation and structural integrity. It shares conserved regions with proteins involved in cilia/flagella assembly, suggesting a role in sperm motility via flagellar formation. Studies in murine models indicate that Spata20 knockout leads to male infertility due to disrupted mitochondrial sheath formation in sperm, highlighting its essentiality in mitochondrial organization during spermiogenesis. Structurally, SPATA20 contains coiled-coil domains, indicative of protein interaction capabilities, though its full tertiary structure remains unresolved. While predominantly linked to reproduction, limited evidence suggests potential involvement in cancers, such as hepatocellular carcinoma, via unclear mechanisms. Current research focuses on elucidating its interactome and post-translational modifications, which may clarify its dual roles in cellular dynamics. Further characterization is needed to define its molecular pathways and therapeutic relevance.
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