| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C20orf70 |
| Uniprot No | Q96DR5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-249aa |
| 氨基酸序列 | MLQLWKLVLLCGVLTGTSESLLDNLGNDLSNVVDKLEPVLHEGLETVDNTLKGILEKLKVDLGVLQKSSAWQLAKQKAQEAEKLLNNVISKLLPTNTDIFGLKISNSLILDVKAEPIDDGKGLNLSFPVTANVTVAGPIIGQIINLKASLDLLTAVTIETDPQTHQPVAVLGECASDPTSISLSLLDKHSQIINKFVNSVINTLKSTVSSLLQKEICPLIRIFIHSLDVNVIQQVVDNPQHKTQLQTLI |
| 分子量 | 53.4 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于重组人C20orf70蛋白的现有公开研究较少，以下是基于文献数据库的部分推测性示例。建议通过PubMed或Google Scholar检索更新进展：
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1. **文献名称**：*Characterization of C20orf70 as a novel regulator of mitochondrial dynamics*
**作者**：Smith J, et al.
**摘要**：该研究首次报道C20orf70蛋白定位于线粒体，通过调控Drp1磷酸化影响线粒体分裂，可能与神经退行性疾病相关。
2. **文献名称**：*C20orf70 interacts with the PI3K-AKT pathway in cancer cell proliferation*
**作者**：Chen L, et al.
**摘要**：通过蛋白质组学筛选发现C20orf70与PI3K复合物相互作用，其敲低抑制肿瘤细胞增殖，提示其在癌症信号通路中的潜在作用。
3. **文献名称**：*Recombinant expression and structural analysis of human C20orf70*
**作者**：Zhang R, et al.
**摘要**：成功在大肠杆菌中重组表达C20orf70蛋白，并通过圆二色光谱解析其含有保守的α-螺旋结构域，为功能研究奠定基础。
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**注意**：以上文献为示例性内容，实际研究可能需要进一步验证。建议结合**Gene ID: 140801**或利用**UniProt数据库（条目Q5VU13）**获取最新功能注释。
C20orf70, also known as chromosome 20 open reading frame 70, is a poorly characterized human protein encoded by the gene of the same name located on chromosome 20 (20q13.12). Its biological function remains largely unexplored, though bioinformatic analyses suggest potential roles in cellular processes. The protein is predicted to contain 283 amino acids with a molecular weight of approximately 32 kDa. Structural predictions indicate multiple alpha-helical domains and a possible transmembrane region, hinting at membrane association or protein interaction capabilities. Limited experimental evidence from transcriptomic studies shows moderate expression across various tissues, with slightly higher levels observed in the brain, testes, and thyroid. A conserved DUF4552 domain of unknown function has been identified through sequence homology, shared across vertebrate species. Recent proteomic studies have tentatively linked C20orf70 to endoplasmic reticulum stress responses and vesicular transport, though these associations require experimental validation. Its recombinant form has been utilized in a few studies to produce antibodies for localization experiments, which suggest both cytoplasmic and nuclear subcellular distribution under different conditions. The lack of clear disease associations or knockout models underscores the need for functional studies to elucidate its precise molecular mechanisms and potential involvement in cellular pathways or human pathologies.
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