| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C20orf43 |
| Uniprot No | Q9BY42 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-306aa |
| 氨基酸序列 | MGCDGGTIPKRHELVKGPKKVEKVDKDAELVAQWNYCTLSQEILRRPIVACELGRLYNKDAVIEFLLDKSAEKALGKAASHIKSIKNVTELKLSDNPAWEGDKGNTKGDKHDDLQRARFICPVVGLEMNGRHRFCFLRCCGCVFSERALKEIKAEVCHTCGAAFQEDDVIVLNGTKEDVDVLKTRMEERRLRAKLEKKTKKPKAAESVSKPDVSEEAPGPSKVKTGKPEEASLDSREKKTNLAPKSTAMNESSSGKAGKPPCGATKRSIADSEESEAYKSLFTTHSSAKRSKEESAHWVTHTSYCF |
| 分子量 | 60.3 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C20orf43蛋白的3篇参考文献及其摘要概括（文献为虚构示例，实际研究请查证数据库）：
1. **文献名称**：*Identification and Functional Characterization of C20orf43 as a Novel Mitochondrial Protein*
**作者**：Zhang L, et al. (2018)
**摘要**：该研究首次报道C20orf43定位于线粒体，通过基因沉默实验发现其缺失导致线粒体功能异常，提示其在能量代谢中可能发挥作用。
2. **文献名称**：*C20orf43 Interacts with the mTOR Pathway and Regulates Cell Proliferation*
**作者**：Smith J, et al. (2020)
**摘要**：研究发现重组人C20orf43蛋白通过结合mTOR复合物调控细胞周期，其过表达抑制肿瘤细胞增殖，表明潜在的抑癌功能。
3. **文献名称**：*Structural Analysis of C20orf43 Reveals a Conserved Domain Associated with Nucleic Acid Binding*
**作者**：Chen H, et al. (2021)
**摘要**：通过晶体结构解析，发现C20orf43含有一个未知功能的保守结构域，体外实验显示其可结合RNA，提示参与转录后调控。
**备注**：C20orf43研究相对较少，上述内容为基于相关领域文献的模拟概括。实际文献需通过PubMed、Google Scholar等平台以“C20orf43”或“chromosome 20 open reading frame 43”检索获取。
Human C20orf43 (Chromosome 20 Open Reading Frame 43), recently reclassified as CFAP20 (Cilia- and Flagella-Associated Protein 20), is a conserved eukaryotic protein encoded by the C20orf43 gene located on chromosome 20 (20q11.21). It is ubiquitously expressed, with higher levels observed in reproductive tissues like the testes, suggesting roles in germ cell development or spermatogenesis. Structurally, it contains a DUF4494 domain and predicted coiled-coil regions, indicative of protein interaction capabilities. Studies link CFAP20 to ciliogenesis and flagellar function, particularly in regulating intraflagellar transport (IFT) and maintaining ciliary structural integrity. Disruption of CFAP20 orthologs in model organisms (e.g., Chlamydomonas) causes defective ciliary motility and signaling. In humans, altered CFAP20 expression has been associated with infertility, ciliopathies, and certain cancers, though mechanistic details remain under investigation. Its interaction with microtubule-associated proteins and involvement in cell cycle progression further suggest roles beyond cilia-related functions. Current research focuses on characterizing its molecular partners and validating its potential as a therapeutic target for related disorders.
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