| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C20orf30 |
| Uniprot No | Q96A57 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-120aa |
| 氨基酸序列 | MMPSRTNLATGIPSSKVKYSRLSSTDDGYIDLQFKKTPPKIPYKAIALATVLFLIGAFLIIIGSLLLSGYISKGGADRAVPVLIIGILVFLPGFYHLRIAYYASKGYRGYSYDDIPDFDD |
| 分子量 | 38.94 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是假设的3篇关于重组人（C20orf30）蛋白的文献示例（实际文献需通过学术数据库验证）：
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1. **文献名称**: *"Functional characterization of C20orf30 as a novel regulator of mitochondrial dynamics"*
**作者**: Zhang L, et al.
**摘要**: 本研究首次报道了C20orf30蛋白定位于线粒体，并通过调控DRP1磷酸化参与线粒体分裂过程。基因敲除实验显示，C20orf30缺失导致线粒体网状结构异常，影响细胞能量代谢。
2. **文献名称**: *"C20orf30 interacts with BRCA1 and modulates DNA damage response in breast cancer cells"*
**作者**: Smith J, et al.
**摘要**: 发现C20orf30通过物理结合BRCA1蛋白增强同源重组修复（HRR）能力。其在乳腺癌组织中的低表达与放疗耐药性相关，提示其可能作为肿瘤治疗的潜在靶点。
3. **文献名称**: *"Structural analysis of recombinant human C20orf30 reveals a redox-sensitive cysteine cluster"*
**作者**: Tanaka K, et al.
**摘要**: 通过X射线晶体学解析了C20orf30的晶体结构（分辨率2.1Å），发现其N端结构域含有保守的半胱氨酸簇，体外实验证实该区域在氧化应激下发生二硫键重构，可能参与细胞抗氧化防御机制。
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**备注**：以上文献为模拟示例，实际研究需检索PubMed、Web of Science等数据库获取。C20orf30作为20号染色体开放阅读框30编码蛋白，目前研究集中在细胞器动力学、癌症关联及结构解析方向。
The recombination-associated protein (C20orf30), also known as FAM20D, is a member of the FAM20 family of secreted proteins. Located on chromosome 20q11.21, this gene encodes a Golgi-localized protein with a putative kinase-like function. While its precise molecular mechanisms remain unclear, FAM20D shares sequence homology with FAM20A and FAM20C, which are known to regulate biomineralization and phosphate metabolism. Emerging studies suggest FAM20D may participate in extracellular matrix organization and cellular signaling pathways, potentially influencing tissue development and homeostasis.
Notably, FAM20D has been implicated in tumorigenesis, with elevated expression observed in certain cancers, including breast and colorectal carcinomas. It may promote cancer cell proliferation and metastasis through interactions with integrins or other adhesion molecules. Additionally, mutations in FAM20D have been associated with rare genetic disorders affecting skeletal and dental development, hinting at its role in mineralization processes. Despite these advances, functional characterization remains limited compared to other FAM20 members. Current research focuses on elucidating its enzymatic activity, substrate specificity, and regulatory networks, particularly in the context of disease pathogenesis. The protein's conserved presence across vertebrates underscores its potential biological significance, warranting further investigation.
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