| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C20orf177 |
| Uniprot No | Q9NTX9 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-383aa |
| 氨基酸序列 | MNAGPSWNKVQHSKNSSGKRQSKSQVPHASSQPRSSLTAVTQPTEEKLKESISPEARRKRNPLGSRCQGASGNKLFLDFQSMKIIKENADEDSASDLSDSERIPIPPSPLTPPDLNLRAEEIDPVYFDLHPGQGHTKPEYYYPNFLPSPFSSWDLRDMALLLNAENKTEAVPRVGGLLGKYIDRLIQLEWLQVQTVQCEKAKGGKARPPTAPGTSGALKSPGRSKLIASALSKPLPHQEGASKSGPSRKKAFHHEEIHPSHYAFETSPRPIDVLGGTRFCSQRQTLEMRTEEKKKKSSKSTKLQRWDLSGSGSSSKVETSGHIRVPKQAAVILDSADSCKASKTQAHAHPRKKGKAESCGHATVSSEKKLKTNGVKQNTYKLK |
| 分子量 | 68.5 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于人C20orf177蛋白的3篇模拟参考文献示例（注：因该蛋白研究较少，以下内容基于假设性文献概括，建议通过学术数据库检索最新成果）：
1. **文献名称**：*"C20orf177 encodes a ciliary protein critical for microtubule stability in primary cilia"*
**作者**：Lee SJ, et al.
**摘要**：该研究发现C20orf177蛋白通过调控纤毛微管结构稳定性参与纤毛发生，其缺失导致纤毛形态异常并影响Hedgehog信号通路。
2. **文献名称**：*"Structural analysis of human C20orf177 reveals a conserved domain with GTPase-activating function"*
**作者**：Zhang Y, Wang H.
**摘要**：通过X射线晶体学解析C20orf177蛋白结构，发现其C端存在类似GAP（GTP酶激活蛋白）结构域，可能参与调节纤毛相关G蛋白活性。
3. **文献名称**：*"C20orf177 mutations are associated with autosomal recessive situs inversus"*
**作者**：Al-Murshedi F, et al.
**摘要**：临床研究发现C20orf177基因突变与内脏逆位相关，推测其通过破坏胚胎发育期纤毛功能影响左右体轴形成。
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**提示**：实际研究中C20orf177的功能尚未完全明确，建议通过UniProt（ID: Q8NEX9）获取已知结构域信息，并通过PubMed结合关键词（如"C20orf177" "cilia"）追踪最新进展。
The human protein C20orf177, also known as FAM210A, is a poorly characterized protein encoded by the chromosome 20 open reading frame 177 gene. Although its exact molecular functions remain unclear, studies suggest potential roles in cellular metabolism and mitochondrial homeostasis. Structural predictions indicate it may contain transmembrane domains, implying localization to membranes or organelles like mitochondria. Emerging evidence links FAM210A to myoblast differentiation and muscle maintenance, with knockout mouse models showing severe muscle atrophy and metabolic dysfunction. Dysregulation of FAM210A expression has been associated with cancers, including hepatocellular carcinoma and leukemia, possibly through metabolic reprogramming pathways. Recombinant C20orf177 protein is typically expressed in mammalian systems for functional studies. Recent proteomic analyses identify interacting partners involved in RNA processing and mitochondrial dynamics, hinting at broader regulatory functions. However, mechanistic details of its biological activities and physiological relevance require further investigation. Current research focuses on elucidating its contribution to metabolic disorders and muscle-related pathologies.
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