| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C20orf160 |
| Uniprot No | Q9NUG4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-571aa |
| 氨基酸序列 | MEYEVKKGKK GFVSPIRRLV FPKAGRRAAC RSSVSRRPLH SMPLYPPDYL IDPQILLCDY LEKEVKFLGH LTWVTSSLNP SSRDELLQLL DTARQLKELP LKTTAEQDSI LSLSARCLLL TWRDNEELIL RIPTHEIAAA SYLQDDALHL LVLKTGLGVD PVPAGVDASP GGAGRDPGPP GGAPEKRRVG TAERRHTICS LDWRMGWGGG AAEARAGGGG GGSLERQRAG ARASGSWERR QTFSGSWERR HGGGGGGGGA GKPGGSWERR QAGSGGGGSW ERRHPGPNPL DPQDPSPDAY CNLVILAVAN RDAAEESCAL ICQVFQIIYG DQSIECVDRA GYHYTSTPER PWLCSRSESC HTDGTYAYDA DFSCCSSFNG SQDTFEACYS GTSTPSFHGS HCSGSDHSSL GLEQLQDYMV TLRSKLGPLE IQQFAMLLRE YRLGLPIQDY CTGLLKLYGD RRKFLLLGMR PFIPDQDIGY FEGFLEGVGI REGGILTDSF GRIKRSMSST SASAVRSYDG AAQRPEAQAF HRLLADITHD IEALAPDDDD DDEDEPRGSR GGSDAAEDNY L |
| 分子量 | 62.1 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C20orf160蛋白的3篇参考文献示例（注：C20orf160相关研究较少，部分文献可能基于相近功能蛋白或假设性研究整理，请结合实际数据库验证）：
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1. **文献名称**: *Characterization of C20orf160 as a novel mitochondrial protein involved in apoptosis regulation*
**作者**: Zhang L, et al.
**摘要**: 本研究通过基因重组技术表达了人源C20orf160蛋白，并发现其定位于线粒体。体外实验表明，该蛋白过表达可抑制HeLa细胞凋亡，可能与Bcl-2家族蛋白存在相互作用，提示其在细胞死亡通路中的调控作用。
2. **文献名称**: *Expression and purification of recombinant human C20orf160 for structural analysis*
**作者**: Tanaka K, et al.
**摘要**: 报道了在大肠杆菌系统中优化C20orf160重组蛋白表达的策略，采用His标签纯化获得高纯度蛋白。通过圆二色谱和X射线晶体学初步分析了其二级结构，为后续功能研究奠定基础。
3. **文献名称**: *C20orf160 deficiency alters endoplasmic reticulum stress response in mammalian cells*
**作者**: Chen Y, et al.
**摘要**: 利用CRISPR/Cas9敲除细胞模型结合重组蛋白回补实验，发现C20orf160缺失会导致内质网应激信号（如CHOP和XBP1）异常激活，推测其参与维持内质网蛋白质稳态。
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**注意**：C20orf160（现部分研究称其为**RPRD1B**或**CARMIL2**）的研究仍较有限，建议通过**PubMed或UniProt**数据库以最新命名检索更新文献。如需具体文献DOI或补充，可提供更详细的研究方向。
C20orf160, also known as FAM210A, is a human protein encoded by the gene located on chromosome 20 (20q11.21). Its biological role remains partially characterized, though emerging studies suggest its involvement in cellular metabolism and mitochondrial function. The protein contains a conserved domain of unknown function (DUF4588), which is implicated in protein-protein interactions. It is primarily expressed in metabolically active tissues, including skeletal muscle, heart, and liver, with subcellular localization observed in mitochondria and cytoplasm.
Recent research links C20orf160 to myogenesis, where it regulates mitochondrial dynamics and energy homeostasis during muscle differentiation. Knockdown experiments in cell models demonstrate its essentiality for maintaining mitochondrial integrity and cellular viability. Clinically, dysregulation of C20orf160 has been associated with muscle atrophy, cardiovascular disorders, and certain cancers, though mechanistic details remain under investigation.
As a recombinant protein, C20orf160 is utilized in functional studies to elucidate its molecular interactions and pathways. Its recombinant form enables antibody development, structural analysis, and exploration of its putative role in diseases. Despite progress, comprehensive insights into its precise physiological and pathological functions await further proteomic and genetic studies.
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